Kenneth B Marcu
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Explore the profile of Kenneth B Marcu including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
2738
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Recent Articles
1.
IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency
Cieniewicz B, Kirillov V, Daher I, Li X, Oldenburg D, Dong Q, et al.
J Virol
. 2022 Apr;
96(10):e0002722.
PMID: 35481781
Noncanonical NF-κB signaling is activated in B cells via the tumor necrosis factor (TNF) receptor superfamily members CD40, lymphotoxin β receptor (LTβR), and B-cell-activating factor receptor (BAFF-R). The noncanonical pathway...
2.
Olivotto E, Minguzzi M, DAdamo S, Astolfi A, Santi S, Uguccioni M, et al.
Sci Rep
. 2021 Nov;
11(1):21697.
PMID: 34737366
IKKα and IKKβ are essential kinases for activating NF-κB transcription factors that regulate cellular differentiation and inflammation. By virtue of their small size, chemokines support the crosstalk between cartilage and...
3.
Roupakia E, Chavdoula E, Karpathiou G, Vatsellas G, Chatzopoulos D, Mela A, et al.
Cancers (Basel)
. 2021 Sep;
13(17).
PMID: 34503110
Background: The development of non-small cell lung cancer (NSCLC) involves the progressive accumulation of genetic and epigenetic changes. These include somatic oncogenic and mutations and inactivating tumour suppressor mutations, leading...
4.
Chavdoula E, Habiel D, Roupakia E, Markopoulos G, Vasilaki E, Kokkalis A, et al.
Life Sci Alliance
. 2019 Dec;
2(6).
PMID: 31792060
Through the progressive accumulation of genetic and epigenetic alterations in cellular physiology, non-small-cell lung cancer (NSCLC) evolves in distinct steps involving mutually exclusive oncogenic mutations in K-Ras or EGFR along...
5.
Markopoulos G, Roupakia E, Marcu K, Kolettas E
Cells
. 2019 Sep;
8(10).
PMID: 31557902
The neoplastic transformation of normal to metastatic cancer cells is a complex multistep process involving the progressive accumulation of interacting genetic and epigenetic changes that alter gene function and affect...
6.
Culley K, Lessard S, Green J, Quinn J, Chang J, Khilnani T, et al.
Sci Rep
. 2019 Jun;
9(1):8905.
PMID: 31222033
CHUK/IKKα contributes to collagenase-driven extracellular matrix remodeling and chondrocyte hypertrophic differentiation in vitro, in a kinase-independent manner. These processes contribute to osteoarthritis (OA), where chondrocytes experience a phenotypic shift towards...
7.
Singh P, Marcu K, Goldring M, Otero M
Ann N Y Acad Sci
. 2018 Jul;
1442(1):17-34.
PMID: 30008181
Articular chondrocytes are quiescent, fully differentiated cells responsible for the homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine-tuned balance between anabolic and catabolic functions. This...
8.
Markopoulos G, Roupakia E, Tokamani M, Alabasi G, Sandaltzopoulos R, Marcu K, et al.
Biomedicines
. 2018 Mar;
6(2).
PMID: 29601548
The NF-κB family of transcription factors regulate the expression of genes encoding proteins and microRNAs (miRNA, miR) precursors that may either positively or negatively regulate a variety of biological processes...
9.
Markopoulos G, Roupakia E, Tokamani M, Chavdoula E, Hatziapostolou M, Polytarchou C, et al.
Cell Oncol (Dordr)
. 2017 Jul;
40(4):303-339.
PMID: 28748501
Background: Cancer is one of the leading causes of mortality. The neoplastic transformation of normal cells to cancer cells is caused by a progressive accumulation of genetic and epigenetic alterations...
10.
Santana A, Oldenburg D, Kirillov V, Malik L, Dong Q, Sinayev R, et al.
Pathogens
. 2017 Feb;
6(1).
PMID: 28212352
RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency. Lipopolysaccharide (LPS)/toll-like receptor (TLR)4 engagement enhances rhadinovirus reactivation....