Kenneth B Marcu
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Explore the profile of Kenneth B Marcu including associated specialties, affiliations and a list of published articles.
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43
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2738
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Recent Articles
11.
Olivotto E, Otero M, Marcu K, Goldring M
RMD Open
. 2015 Nov;
1(Suppl 1):e000061.
PMID: 26557379
Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence, representing a severe health burden with a...
12.
Penzo M, Habiel D, Ramadass M, Kew R, Marcu K
Biochim Biophys Acta
. 2014 Apr;
1843(9):1796-1804.
PMID: 24747690
CXCL12 and its unique receptor CXCR4, is critical for the homing of a variety of cell lineages during both development and tissue repair. CXCL12 is particularly important for the recruitment...
13.
Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, et al.
PLoS One
. 2013 Sep;
8(9):e73024.
PMID: 24023802
Background: The non-canonical NF-κB activating kinase IKKα, encoded by CHUK (conserved-helix-loop-helix-ubiquitous-kinase), has been reported to modulate pro- or anti- inflammatory responses, cellular survival and cellular differentiation. Here, we have investigated...
14.
Hashimoto K, Otero M, Imagawa K, de Andres M, Coico J, Roach H, et al.
J Biol Chem
. 2013 Feb;
288(14):10061-10072.
PMID: 23417678
The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B, which have sparse CpG islands, is poorly understood in the context of musculoskeletal diseases....
15.
Samaniego S, Marcu K
PLoS One
. 2013 Jan;
8(1):e54124.
PMID: 23349802
Background: The NF-κB activating kinases, IKKα and IKKβ, are key regulators of inflammation and immunity in response to infection by a variety of pathogens. Both IKKα and IKKβ have been...
16.
Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, et al.
Cell Signal
. 2012 Jul;
24(11):2007-23.
PMID: 22750558
DNA damage responses (DDR) invoke senescence or apoptosis depending on stimulus intensity and the degree of activation of the p53-p21(Cip1/Waf1) axis; but the functional impact of NF-κB signaling on these...
17.
Kew R, Penzo M, Habiel D, Marcu K
J Immunol
. 2012 Jan;
188(5):2380-6.
PMID: 22287708
HMGB1 is a chromatin architectural protein that is released by dead or damaged cells at sites of tissue injury. Extracellular HMGB1 functions as a proinflammatory cytokine and chemoattractant for immune...
18.
Goldring M, Marcu K
Trends Mol Med
. 2011 Dec;
18(2):109-18.
PMID: 22178468
Osteoarthritis (OA) is a multifactorial disease subject to the effects of many genes and environmental factors. Alterations in the normal pattern of chondrocyte gene control in cartilage facilitate the onset...
19.
Otero M, Plumb D, Tsuchimochi K, Dragomir C, Hashimoto K, Peng H, et al.
J Biol Chem
. 2011 Dec;
287(5):3559-72.
PMID: 22158614
Matrix metalloproteinase (MMP)-13 has a pivotal, rate-limiting function in cartilage remodeling and degradation due to its specificity for cleaving type II collagen. The proximal MMP13 promoter contains evolutionarily conserved E26...
20.
Zheng Y, Lilo S, Brodsky I, Zhang Y, Medzhitov R, Marcu K, et al.
PLoS Pathog
. 2011 May;
7(4):e1002026.
PMID: 21533069
A type III secretion system (T3SS) in pathogenic Yersinia species functions to translocate Yop effectors, which modulate cytokine production and regulate cell death in macrophages. Distinct pathways of T3SS-dependent cell...