Kenji Mishiro
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Explore the profile of Kenji Mishiro including associated specialties, affiliations and a list of published articles.
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51
Citations
192
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Recent Articles
1.
Ogawa K, Kobayashi R, Okada N, Mishiro K
Chemistry
. 2025 Mar;
:e202500187.
PMID: 40067166
Phosphate and sulfate groups play an important role in controlling the physical properties of biomolecules and artificial materials. However, despite their significance, the incorporation of phosphate or sulfate groups into...
2.
Fuchigami T, Shimo K, Hiwatashi T, Andoh Y, Munekane M, Mishiro K, et al.
Mol Pharm
. 2025 Mar;
PMID: 40066788
Radiopharmaceuticals targeting tumor-specific environments are powerful tools for cancer diagnosis and treatment. We previously demonstrated the considerable high tumor uptake of the cationic amphiphilic peptide, Ga-NOTA-KV6, in vivo. However, because...
3.
Hirata S, Mishiro K, Washiyama K, Munekane M, Fuchigami T, Arano Y, et al.
J Med Chem
. 2025 Jan;
68(2):1540-1552.
PMID: 39757786
At is a promising radiohalogen for targeted α therapy. However, some astatinated compounds undergo deastatination in vivo, leading to unintended astatine accumulation in nontarget tissues. Recently, a group reported that...
4.
Munekane M, Ozaki M, Mitani Y, Sakaida N, Sano K, Yamasaki T, et al.
Mol Pharm
. 2024 Oct;
21(11):5728-5735.
PMID: 39445871
In this study, thermosensitive liposomes (TSLs) encapsulating urinary excretable radiolabeled compounds were developed. We considered that the release of the radiolabeled compounds from the TSLs in the blood by heating...
5.
Ogawa K, Nishizawa K, Mishiro K, Munekane M, Fuchigami T, Echigo H, et al.
Molecules
. 2024 Sep;
29(17).
PMID: 39274840
Acidic amino acid peptides have a high affinity for bone. Previously, we demonstrated that radiogallium complex-conjugated oligo-acidic amino acids possess promising properties as bone-seeking radiopharmaceuticals. Here, to elucidate the effect...
6.
Mogami S, Baba M, Furuyama T, Kunishima M, Mishiro K
J Org Chem
. 2024 Jul;
89(15):10709-10718.
PMID: 39012307
This study developed reactions for the phototriggered generation of reactive ynol ethers using alkoxycyclopropenones. The resulting ynol ethers underwent rearrangement to ketenes, which subsequently participated in cycloaddition with alkynes and...
7.
Ogawa K, Nishizawa K, Mishiro K, Effendi N, Fuchigami T, Munekane M, et al.
Mol Pharm
. 2024 Apr;
21(5):2375-2382.
PMID: 38573777
We investigated the importance of the carboxy group density in bone affinity during the development of peptide-based bone-seeking radiopharmaceuticals and carriers. Oligo-γ-carboxy glutamic acid peptides [(Gla)] with higher carboxy group...
8.
Echigo H, Munekane M, Fuchigami T, Washiyama K, Mishiro K, Wakabayashi H, et al.
Eur J Nucl Med Mol Imaging
. 2024 Apr;
51(9):2663-2671.
PMID: 38570359
Purpose: A probe for targeted alpha therapy (TAT) using the RGD peptide (Ga-DOTA-K([At]APBA)-c(RGDfK) ([At]1)) with albumin-binding moiety (ABM) was recently developed. [At]1 highly accumulated in tumors and significantly inhibited tumor...
9.
Fawwaz M, Mishiro K, Arwansyah A, Nishii R, Ogawa K
Bioimpacts
. 2024 Feb;
14(1):27774.
PMID: 38327635
Introduction: Imaging a non-small cell lung cancer (NSCLC) using radiolabeled tyrosine kinase inhibitors (TKIs) has attracted attention due to their unique interaction with the target epidermal growth factor receptor (EGFR)....
10.
Mishiro K, Sesumi A, Fujii T, Furuyama T, Kunishima M
Org Lett
. 2023 Dec;
26(1):380-384.
PMID: 38153695
A phototriggered conjugation reaction of an aminocyclobutenedione and an acidic nucleophile was discovered. Upon blue light irradiation of the materials, a butenolide derivative with substituents derived from the aminocyclobutenedione and...