Kengo Uemura
Overview
Explore the profile of Kengo Uemura including associated specialties, affiliations and a list of published articles.
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60
Citations
1230
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Recent Articles
1.
Nishida N, Nagata N, Shimoji K, Jingami N, Uemura K, Ozaki A, et al.
Front Aging Neurosci
. 2024 Apr;
16:1364325.
PMID: 38638193
Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called the glymphatic system. Tau is a representative waste...
2.
Asada-Utsugi M, Uemura K, Ayaki T, Uemura M, Minamiyama S, Hikiami R, et al.
Commun Biol
. 2022 Apr;
5(1):358.
PMID: 35418705
DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells. Since tau...
3.
Jingami N, Uemura K, Asada-Utsugi M, Kuzuya A, Yamada S, Ishikawa M, et al.
J Alzheimers Dis
. 2019 Sep;
72(1):271-277.
PMID: 31561378
Background: Extensive research into cerebrospinal fluid (CSF) biomarkers was performed in patients with idiopathic normal pressure hydrocephalus (iNPH). Most prior research into CSF biomarkers has been one-point observation. Objective: To...
4.
Noda Y, Kuzuya A, Tanigawa K, Araki M, Kawai R, Ma B, et al.
Mol Brain
. 2018 Oct;
11(1):61.
PMID: 30355327
The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer's disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role...
5.
Uemura M, Ihara M, Maki T, Nakagomi T, Kaji S, Uemura K, et al.
Brain Pathol
. 2017 May;
28(4):521-535.
PMID: 28470822
Subcortical small vessel disease (SVD) is characterized by white matter damage resulting from arteriolosclerosis and chronic hypoperfusion. Transforming growth factor beta 1 (TGFB1) is dysregulated in the hereditary SVD, CARASIL...
6.
Hamatani M, Jingami N, Tsurusaki Y, Shimada S, Shimojima K, Asada-Utsugi M, et al.
J Hum Genet
. 2016 Jun;
61(10):899-902.
PMID: 27251004
Even now, only a portion of leukodystrophy patients are correctly diagnosed, though various causative genes have been identified. In the present report, we describe a case of adult-onset leukodystrophy in...
7.
Hamatani M, Jingami N, Uemura K, Nakasone N, Kinoshita H, Yamakado H, et al.
Rinsho Shinkeigaku
. 2016 May;
56(6):424-9.
PMID: 27181747
A 40-year-old man was referred to our hospital because of vertical supranuclear gaze palsy, frequent sudden loss of muscle tonus and ataxia for several years. He had a history of...
8.
Honda M, Minami I, Tooi N, Morone N, Nishioka H, Uemura K, et al.
Biochem Biophys Res Commun
. 2015 Dec;
469(3):587-92.
PMID: 26687948
Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), are promising materials for...
9.
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, et al.
Mol Brain
. 2015 Dec;
8(1):82.
PMID: 26637371
Background: Alzheimer's disease (AD) is characterized by senile plaques, extracellular deposits composed primarily of amyloid-beta (Aβ), and neurofibrillary tangles, which are abnormal intracellular inclusions containing hyperphosphorylated tau. The amyloid cascade...
10.
Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, et al.
PLoS One
. 2015 Sep;
10(9):e0131199.
PMID: 26414661
Obesity and type 2 diabetes are risk factors of Alzheimer's disease (AD). We reported that a high fat diet (HFD) promotes amyloid precursor protein (APP) cleavage by β-site APP cleaving...