Masato Maesako
Overview
Explore the profile of Masato Maesako including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
535
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Recent Articles
1.
Arafi P, Devkota S, Williams E, Maesako M, Wolfe M
Elife
. 2025 Feb;
13.
PMID: 39932776
Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer's disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing...
2.
Zellmer J, Tarantino M, Kim M, Lomoio S, Maesako M, Hajnoczky G, et al.
Alzheimers Dement
. 2024 Dec;
21(2):e14417.
PMID: 39713841
Introduction: We previously demonstrated that regulating mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) affects axonal Aβ generation in a well-characterized three-dimensional (3D) neural Alzheimer's disease (AD) model. MAMs vary in thickness...
3.
Perrin F, Anderson L, Mitchell S, Sinha P, Turchyna Y, Maesako M, et al.
Acta Neuropathol Commun
. 2024 Oct;
12(1):166.
PMID: 39434170
The recently discovered interaction between presenilin 1 (PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major brain glutamate transporter (EAAT2 in the human), may...
4.
Sinha P, Turchyna Y, Mitchell S, Sadek M, Armagan G, Perrin F, et al.
Cells
. 2024 Oct;
13(19.
PMID: 39404364
Glutamate transporter-1 (GLT-1) dynamics are implicated in excitotoxicity and Alzheimer's disease (AD) progression. Early stages of AD are often marked by hyperactivity and increased epileptiform activity preceding cognitive decline. Previously,...
5.
Hou S, Ikegawa Y, Kwon Y, Wieckiewicz N, Houser M, Lundin B, et al.
Elife
. 2024 Oct;
13.
PMID: 39360803
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity...
6.
Arafi P, Devkota S, Williams E, Maesako M, Wolfe M
bioRxiv
. 2024 Sep;
PMID: 39257787
Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer's disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing...
7.
Zoltowska K, Das U, Lismont S, Enzlein T, Maesako M, Houser M, et al.
Elife
. 2024 Jul;
12.
PMID: 39027984
Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer's disease (AD). However, molecular cascades underlying their toxicity are poorly defined. Here, we explored a novel hypothesis...
8.
Miller M, Lariviere L, Pagnier G, Aygar S, Wieckiewicz N, Maesako M, et al.
J Alzheimers Dis
. 2024 Apr;
99(2):477-483.
PMID: 38669543
Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a protective and therapeutic treatment for AD...
9.
Perrin F, Sinha P, Mitchell S, Sadek M, Maesako M, Berezovska O
J Biol Chem
. 2024 Mar;
300(4):107172.
PMID: 38499151
The recently discovered interaction between Presenilin 1 (PS1), a catalytic subunit of γ-secretase responsible for generating amyloid-β peptides, and GLT-1, a major glutamate transporter in the brain (EAAT2), provides a...
10.
Hou S, Ikegawa Y, Kwon Y, Wieckiewicz N, Houser M, Lundin B, et al.
bioRxiv
. 2024 Feb;
PMID: 38352497
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Forster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity...