Shun Shimohama
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Explore the profile of Shun Shimohama including associated specialties, affiliations and a list of published articles.
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200
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3213
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Recent Articles
1.
Kato T, Nishimura K, Hirao M, Shimohama S, Takata K
Neuropsychopharmacol Rep
. 2023 Jun;
43(3):440-445.
PMID: 37366076
Aim: Nicotinic acetylcholine receptors (nAChRs) expressed in midbrain dopaminergic (mDA) neurons modulate mDA neuronal activity. However, their expression patterns and functional roles during mDA neuronal development remain unknown. Here, we...
2.
Nonaka T, Ebisu I, Ohashi I, Shizukawa H, Shimohama S
Rinsho Shinkeigaku
. 2022 Jul;
62(8):615-620.
PMID: 35871563
A 51-year-old Japanese man presenting with a several-month history of parasomnia, orthostatic hypotension and generalized myokymia was admitted to our hospital. He had a past medical history of unresectable recurrent...
3.
Miyanaga R, Tanaka M, Nonaka T, Shizukawa H, Shimohama S
Rinsho Shinkeigaku
. 2022 Jun;
62(6):464-468.
PMID: 35644578
A 42-year-old woman presented at our hospital with acute paraphasia and word finding difficulty. She was not paralyzed or ataxic. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) was...
4.
Takata K, Kimura H, Yanagisawa D, Harada K, Nishimura K, Kitamura Y, et al.
Molecules
. 2022 May;
27(9).
PMID: 35566132
Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early...
5.
Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, et al.
JAMA Neurol
. 2022 May;
79(6):575-583.
PMID: 35532908
Importance: The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there is a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin to be...
6.
Hayashi T, Matsushita T, Hisahara S, Iwahara N, Kuno A, Kunimoto R, et al.
J Biochem
. 2021 Oct;
171(2):201-213.
PMID: 34718606
SIRT3 is an NAD+-dependent protein deacetylase localized in mitochondria. Several studies reported localization of SIRT3 in the cytoplasm or nucleus, but data of these studies were not consistent. We detected...
7.
Oda R, Fujikura M, Hayashi T, Matsuya M, Sone J, Shimohama S
Rinsho Shinkeigaku
. 2021 Oct;
61(11):727-732.
PMID: 34657918
A 70-year-old woman presented with a 6-year history of cognitive dysfunction, neurogenic bladder, constipation and recurrent vomiting, and gradual worsening of symptoms. At the first admission to our department, she...
8.
Yano T, Hisahara S, Nagano N, Noto T, Ogawa T, Nishikawa R, et al.
Int Heart J
. 2021 Sep;
62(5):1176-1181.
PMID: 34544983
Sarcoidosis is a systemic inflammatory disease characterized by the formation of noncaseating epithelioid granulomas. Multiple organs, including the lung, eyes, and skin, are involved in this disorder, and cardiac involvement...
9.
Takata K, Ginhoux F, Shimohama S
Biochem Pharmacol
. 2021 Sep;
192:114754.
PMID: 34480881
Microglia are specialized macrophages that reside within the central nervous system and play key roles in brain immunity, development and homeostasis. Recent studies also revealed functions of microglia in neuroprotection...
10.
Amimoto N, Nishimura K, Shimohama S, Takata K
Stem Cell Res
. 2021 Aug;
55:102486.
PMID: 34385043
Human induced pluripotent stem cells (hiPSCs) are powerful tools for modeling human brain development and treating neurodegenerative diseases. Here we established a robust protocol with high scalability for generating striatal...