Kendra Marcus
Overview
Explore the profile of Kendra Marcus including associated specialties, affiliations and a list of published articles.
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7
Citations
97
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Recent Articles
1.
Marcus K, Huang Y, Subramanian S, Gee C, Gorday K, Ghaffari-Kashani S, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(3):424-435.
PMID: 38177685
Clamp loaders are AAA+ ATPases that facilitate high-speed DNA replication. In eukaryotic and bacteriophage clamp loaders, ATP hydrolysis requires interactions between aspartate residues in one protomer, present in conserved 'DEAD-box'...
2.
Yang K, Wang C, Kreutzberger A, Ojha R, Kuivanen S, Couoh-Cardel S, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(40):e2210990119.
PMID: 36122200
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available coronavirus disease 2019 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the...
3.
Yang K, Wang C, Kreutzberger A, Ojha R, Kuivanen S, Couoh-Cardel S, et al.
bioRxiv
. 2022 Aug;
PMID: 35982670
Significance Statement: SARS-CoV-2 infection requires fusion of viral and host membranes, mediated by the viral spike glycoprotein (S). Due to the importance of viral membrane fusion, S has been a...
4.
Subramanian S, Gorday K, Marcus K, Orellana M, Ren P, Luo X, et al.
Elife
. 2021 Apr;
10.
PMID: 33847559
Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found...
5.
Jang H, Banerjee A, Marcus K, Makowski L, Mattos C, Gaponenko V, et al.
Structure
. 2019 Sep;
27(11):1647-1659.e4.
PMID: 31495533
Ca-calmodulin (CaM) extracts KRas4B from the plasma membrane, suggesting that KRas4B/CaM interaction plays a role in regulating Ras signaling. To gain mechanistic insight, we provide a computational model, supported by...
6.
Marcus K, Mattos C
J Comput Chem
. 2019 Sep;
41(5):402-414.
PMID: 31483874
The Ras GTPase superfamily of proteins coordinates a diverse set of cellular outcomes, including cell morphology, vesicle transport, and cell proliferation. Primary amino acid sequence analysis has identified Specificity determinant...
7.
Marcus K, Mattos C
Clin Cancer Res
. 2015 Apr;
21(8):1810-8.
PMID: 25878362
The crystal structure of RAS was first solved 25 years ago. In spite of tremendous and sustained efforts, there are still no drugs in the clinic that directly target this...