Axel T Brunger
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Explore the profile of Axel T Brunger including associated specialties, affiliations and a list of published articles.
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165
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9180
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Recent Articles
1.
Held R, Liang J, Esquivies L, Khan Y, Wang C, Azubel M, et al.
bioRxiv
. 2024 Oct;
PMID: 39464045
Most synapses in the brain transmit information by the presynaptic release of vesicular glutamate, driving postsynaptic depolarization through AMPA-type glutamate receptors (AMPARs). The nanometer-scale topography of synaptic AMPARs regulates response...
2.
White K, Khan Y, Qiu K, Balaji A, Couoh-Cardel S, Esquivies L, et al.
bioRxiv
. 2024 Oct;
PMID: 39416070
Membrane fusion is driven by SNARE complex formation across cellular contexts, including vesicle fusion during synaptic transmission. Multiple proteins organize trans-SNARE complex assembly and priming, leading to fusion. One target...
3.
Khan Y, White K, Pfuetzner R, Singal B, Esquivies L, Mckenzie G, et al.
bioRxiv
. 2024 Sep;
PMID: 39257774
SNARE proteins drive membrane fusion as their core domains zipper into a parallel four-helix bundle. After fusion, these bundles are disassembled by the AAA+ protein Sec18/NSF and its adaptor Sec17/...
4.
Leitz J, Wang C, Esquivies L, Peters J, Gopal N, Pfuetzner R, et al.
Nat Protoc
. 2024 Jul;
19(11):3139-3161.
PMID: 38956381
Here, we present a protocol for isolating functionally intact glutamatergic synaptic vesicles from whole-mouse brain tissue and using them in a single-vesicle assay to examine their association and fusion with...
5.
Wang C, Zhang K, Cai B, Haller J, Carnazza K, Hu J, et al.
Nat Cell Biol
. 2024 Jul;
26(8):1287-1295.
PMID: 38951706
α-Synuclein (α-Syn) aggregation is closely associated with Parkinson's disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. However, the underlying...
6.
Held R, Liang J, Brunger A
Proc Natl Acad Sci U S A
. 2024 Jun;
121(27):e2403136121.
PMID: 38923992
The spatial distribution of proteins and their arrangement within the cellular ultrastructure regulates the opening of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in response to glutamate release at the synapse. Fluorescence microscopy...
7.
Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, et al.
Nature
. 2024 Jun;
631(8022):899-904.
PMID: 38838737
Synaptic vesicles are organelles with a precisely defined protein and lipid composition, yet the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here we discovered a well-defined...
8.
Leitz J, Wang C, Esquivies L, Pfuetzner R, Peters J, Couoh-Cardel S, et al.
Cell Rep
. 2024 May;
43(5):114026.
PMID: 38809756
Synaptic vesicle docking and priming are dynamic processes. At the molecular level, SNAREs (soluble NSF attachment protein receptors), synaptotagmins, and other factors are critical for Ca-triggered vesicle exocytosis, while disassembly...
9.
Gopal N, Leitz J, Wang C, Esquivies L, Pfuetzner R, Brunger A
Curr Res Physiol
. 2024 Apr;
7:100121.
PMID: 38572021
Synaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a...
10.
Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(44):e2310174120.
PMID: 37883437
α-synuclein (α-Syn) is a presynaptic protein that is involved in Parkinson's and other neurodegenerative diseases and binds to negatively charged phospholipids. Previously, we reported that α-Syn clusters synthetic proteoliposomes that...