Ken Sakurai
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Explore the profile of Ken Sakurai including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
329
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Recent Articles
11.
Akiu M, Tsuji T, Iida K, Sogawa Y, Terayama K, Yokoyama M, et al.
Chem Pharm Bull (Tokyo)
. 2021 Nov;
69(11):1110-1122.
PMID: 34719594
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the nicotinamide adenine dinucleotide (NAD) salvage pathway. Because NAD plays a pivotal role in energy metabolism and boosting NAD has positive effects...
12.
Okajima D, Yasuda S, Maejima T, Karibe T, Sakurai K, Aida T, et al.
Mol Cancer Ther
. 2021 Aug;
20(12):2329-2340.
PMID: 34413126
Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. We developed the novel TROP2-directed antibody-drug conjugate (ADC), datopotamab deruxtecan (Dato-DXd, DS-1062a),...
13.
Akiu M, Tsuji T, Sogawa Y, Terayama K, Yokoyama M, Tanaka J, et al.
Bioorg Med Chem Lett
. 2021 Apr;
43:128048.
PMID: 33887438
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the NAD salvage pathway. Since NAD plays a pivotal role in many biological processes including metabolism and aging, activation of NAMPT is...
14.
Morimoto S, Nojiri A, Fukuro E, Anan I, Kawai M, Sakurai K, et al.
Front Cardiovasc Med
. 2021 Feb;
7:614129.
PMID: 33521063
An electrocardiogram (ECG) is an important tool for demonstrating cardiac manifestations in various heart diseases. The present study clarified the characteristics of ECG parameters in Japanese Fabry patients under long-term...
15.
Nahrendorf M, Hoyer F, Meerwaldt A, van Leent M, Senders M, Calcagno C, et al.
Circ Cardiovasc Imaging
. 2020 Oct;
13(10):e010586.
PMID: 33076700
Background: Macrophages, innate immune cells that reside in all organs, defend the host against infection and injury. In the heart and vasculature, inflammatory macrophages also enhance tissue damage and propel...
16.
Chiba K, Ishizaka T, Yoshimatsu Y, Mikamoto K, Maeda Y, Iguchi T, et al.
J Pharmacol Toxicol Methods
. 2020 May;
103:106870.
PMID: 32353509
The objective of this study was to elucidate the underlying cardiotoxic mechanism of milrinone, a cAMP phosphodiesterase 3 inhibitor, by evaluating cardiac functions, blood biomarkers including cardiac troponin I (cTnI),...
17.
Kabata R, Okuda H, Noguchi A, Kondo D, Fujiwara M, Hata K, et al.
PLoS One
. 2018 Dec;
13(12):e0208516.
PMID: 30557356
We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A...
18.
Sakurai K, Ohashi T, Shimozawa N, Joo-Hyun S, Okuyama T, Ida H
Brain Dev
. 2018 Aug;
41(1):50-56.
PMID: 30077509
Objective: Early diagnosis is critical in achieving the best outcome following hematopoietic stem cell transplantation (HSCT) for X-linked adrenoleukodystrophy (X-ALD). We used a questionnaire to gather detailed clinical information and...
19.
Motoyama K, Nagata T, Kobayashi J, Nakamura A, Miyoshi N, Kazui M, et al.
Bioorg Med Chem Lett
. 2018 May;
28(12):2222-2227.
PMID: 29752182
In this study, we aimed to synthesize a novel blocker of transient receptor potential canonical 6 (TRPC6). The sp carbon atoms of the aminoindane skeleton of the known inhibitor were...
20.
Iguchi T, Niino N, Tamai S, Sakurai K, Mori K
J Vis Exp
. 2018 Mar;
(132).
PMID: 29553521
RT-qPCR is one of the most common methods to assess individual target miRNAs. MiRNAs levels are generally measured relative to a reference sample. This approach is appropriate for examining physiological...