Ken Sakurai
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Explore the profile of Ken Sakurai including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
329
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Recent Articles
21.
Iguchi T, Sakurai K, Tamai S, Mori K
J Toxicol Pathol
. 2018 Feb;
31(1):3-13.
PMID: 29479135
Circulating microRNAs (miRNAs) can potentially be used as sensitive and specific biomarkers for tissue injury. However, the usefulness of circulating miRNAs as safety biomarkers in nonclinical toxicological studies using nonhuman...
22.
Iguchi T, Niino N, Tamai S, Sakurai K, Mori K
Int J Toxicol
. 2017 May;
36(3):220-228.
PMID: 28460582
Circulating microRNAs (miRNAs) could represent sensitive and specific biomarkers for tissue injury. However, their utility as biomarkers in nonclinical toxicological studies using nonhuman primates is limited by a lack of...
23.
Tamai S, Iguchi T, Niino N, Mikamoto K, Sakurai K, Sayama A, et al.
J Toxicol Sci
. 2017 Jan;
42(1):73-84.
PMID: 28070111
Species-specific differences in the hepatotoxicity of acetaminophen (APAP) have been shown. To establish a monkey model of APAP-induced hepatotoxicity, which has not been previously reported, APAP at doses up to...
24.
Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, et al.
J Appl Toxicol
. 2016 Apr;
36(12):1614-1621.
PMID: 27071960
To characterize microRNAs (miRNAs) involved in testicular toxicity in cynomolgus monkeys, miRNA profiles were investigated using next-generation sequencing (NGS), microarray and reverse transcription-quantitative real-time-PCR (RT-qPCR) methods. First, to identify organ-specific...
25.
Satoh H, Nomiya N, Imai D, Sato S, Sakurai K, Takasuna K, et al.
J Appl Toxicol
. 2015 May;
36(2):266-70.
PMID: 25994107
To establish a method for estimating the glomerular filtration rate (GFR) in conscious monkeys, the radiographic contrast medium iodixanol and the standard agent inulin were coadministered as tracers to male...
26.
Sakurai K, Mikamoto K, Shirai M, Iguchi T, Ito K, Takasaki W, et al.
J Toxicol Sci
. 2015 May;
40(3):375-82.
PMID: 25972197
To establish and characterize ethylene glycol monomethyl ether (EGME)-induced testicular toxicity model in cynomolgus monkeys, EGME at 0 or 300 mg/kg was administered orally to sexually mature male cynomolgus monkeys...
27.
Sakurai K, Matsuoka T, Suzuki C, Kinoshita J, Takayama G, Shimomura K
Reprod Toxicol
. 2014 Sep;
49:162-70.
PMID: 25194688
Very late antigen-4 (VLA-4), which is concerned with cell-cell adhesion, plays important roles in development of the heart, and some VLA-4 antagonists cause cardiac anomalies. In this study, we evaluated...
28.
Iwama R, Sato T, Sakurai K, Takasuna K, Ichijo T, Furuhama K, et al.
J Vet Med Sci
. 2014 Jul;
76(10):1423-6.
PMID: 24998395
To estimate the glomerular filtration rate (GFR) in cynomolgus monkeys (Macaca fascicularis), a three-blood-sample method using iodixanol was assessed in comparison with the conventional multisample strategy using inulin. Iodixanol and...
29.
Tamai M, Kawano T, Saito R, Sakurai K, Saito Y, Yamada H, et al.
Int J Hematol
. 2014 Jun;
100(4):393-7.
PMID: 24934115
Phosphoglycerate kinase (PGK) deficiency, a rare X-linked inherited disorder, manifests as various combinations of hemolytic anemia, neurological dysfunction, and myopathy. We report a Japanese boy with PGK deficiency presenting as...
30.
Ikemoto S, Sakurai K, Kuwashima N, Saito Y, Miyata I, Katsumata N, et al.
Clin Pediatr Endocrinol
. 2013 Aug;
21(1):11-3.
PMID: 23926405
No abstract available.