Kelly C Falls-Hubert
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Explore the profile of Kelly C Falls-Hubert including associated specialties, affiliations and a list of published articles.
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10
Citations
99
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Recent Articles
1.
Rauckhorst A, Sheldon R, Pape D, Ahmed A, Falls-Hubert K, Merrill R, et al.
Cell Metab
. 2024 Oct;
37(1):255-273.e6.
PMID: 39471817
Hepatic de novo lipogenesis (DNL) is a fundamental physiologic process that is often pathogenically elevated in metabolic disease. Treatment is limited by incomplete understanding of the metabolic pathways supplying cytosolic...
2.
Pape D, Falls-Hubert K, Merrill R, Ahmed A, Qian Q, McGivney G, et al.
bioRxiv
. 2024 Sep;
PMID: 39314408
Hepatic gluconeogenesis (GNG) is essential for maintaining euglycemia during prolonged fasting. However, GNG becomes pathologically elevated and drives chronic hyperglycemia in type 2 diabetes (T2D). Lactate/pyruvate is a major GNG...
3.
Carter C, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, et al.
Cell Metab
. 2022 Nov;
34(11):1893.
PMID: 36323238
No abstract available.
4.
Carter C, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, et al.
Am J Physiol Endocrinol Metab
. 2021 Apr;
320(5):E1004-E1005.
PMID: 33843283
No abstract available.
5.
Carter C, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, et al.
Am J Physiol Endocrinol Metab
. 2021 Apr;
320(5):E1001-E1002.
PMID: 33843282
No abstract available.
6.
Carter C, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, et al.
Cell Metab
. 2020 Dec;
32(6):1076.
PMID: 33264599
No abstract available.
7.
Carter C, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, et al.
Cell Metab
. 2020 Oct;
32(4):561-574.e7.
PMID: 33027675
Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic redox homeostasis have had limited success. A noninvasive, sustained...
8.
Stolwijk J, Falls-Hubert K, Searby C, Wagner B, Buettner G
Redox Biol
. 2020 Apr;
32:101518.
PMID: 32278283
Selenium is a metalloid trace element essential for maintaining the optimal redox environment in cells and tissues. It is structurally incorporated into over 25 selenoproteins and enzymes. The glutathione peroxidase...
9.
Gibson A, OLeary B, Du J, Sarsour E, Kalen A, Wagner B, et al.
Cancer Res
. 2020 Feb;
80(7):1401-1413.
PMID: 32041838
Pharmacologic ascorbate treatment (P-AscH, high-dose, intravenous vitamin C) results in a transient short-term increase in the flux of hydrogen peroxide that is preferentially cytotoxic to cancer cells versus normal cells....
10.
Falls-Hubert K, Butler A, Gui K, Anderson M, Li M, Stolwijk J, et al.
Free Radic Biol Med
. 2020 Feb;
150:1-11.
PMID: 32032663
Therapies for lung cancer patients initially elicit desirable responses, but the presence of hypoxia and drug resistant cells within tumors ultimately lead to treatment failure. Disulfiram (DSF) is an FDA...