Keith Pitts
Overview
Explore the profile of Keith Pitts including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
495
Followers
0
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Recent Articles
1.
Kurnik M, Sahin C, Andersen C, Lorenzen N, Giehm L, Mohammad-Beigi H, et al.
Cell Chem Biol
. 2018 Sep;
25(11):1389-1402.e9.
PMID: 30197194
α-Synuclein (αSN) aggregation is central to the etiology of Parkinson's disease (PD). Large-scale screening of compounds to identify aggregation inhibitors is challenged by stochastic αSN aggregation and difficulties in detecting...
2.
Ying D, Hlaing M, Lerisson J, Pitts K, Cheng L, Sanguansri L, et al.
Food Res Int
. 2017 Sep;
100(Pt 1):665-673.
PMID: 28873735
Olive pomace, a waste stream from olive oil processing, was fractionated by centrifugation to obtain a supernatant and a flesh-enriched fraction, and freeze dried to obtain a powder. The dried...
3.
Fauber B, Dragovich P, Chen J, Corson L, Ding C, Eigenbrot C, et al.
Bioorg Med Chem Lett
. 2013 Sep;
23(20):5533-9.
PMID: 24012183
A 2-amino-5-aryl-pyrazine was identified as an inhibitor of human lactate dehydrogenase A (LDHA) via a biochemical screening campaign. Biochemical and biophysical experiments demonstrated that the compound specifically interacted with human...
4.
Wong A, Pitts K, Jayasena V, Johnson S
J Sci Food Agric
. 2013 Jun;
93(15):3755-62.
PMID: 23722992
Background: Australian sweet lupin (ASL) protein is conventionally isolated by alkaline extraction/acid precipitation, leaving a waste stream containing acid-soluble proteins (ASPs) and contaminating raffinose family oligosaccharides (RFOs). The foaming functionality...
5.
Dragovich P, Fauber B, Corson L, Ding C, Eigenbrot C, Ge H, et al.
Bioorg Med Chem Lett
. 2013 May;
23(11):3186-94.
PMID: 23628333
A novel 2-thio-6-oxo-1,6-dihydropyrimidine-containing inhibitor of human lactate dehydrogenase (LDH) was identified by high-throughput screening (IC50=8.1 μM). Biochemical, surface plasmon resonance, and saturation transfer difference NMR experiments indicated that the compound...
6.
Maurer T, Garrenton L, Oh A, Pitts K, Anderson D, Skelton N, et al.
Proc Natl Acad Sci U S A
. 2012 Mar;
109(14):5299-304.
PMID: 22431598
The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although Ras is a central oncogene, small molecules that bind to Ras in a well-defined manner and...
7.
Di Grandi M, Olson M, Prashad A, Bebernitz G, Luckay A, Mullen S, et al.
Bioorg Med Chem Lett
. 2009 Nov;
20(1):398-402.
PMID: 19939680
Two classes of compounds, thiocarbamates 1 and triazoles 2, have been identified as HIV RT RNase H inhibitors using a novel FRET-based HTS assay. The potent analogs in each series...
8.
Moore W, Kern J, Bhat R, Bodine P, Fukyama S, Krishnamurthy G, et al.
Bioorg Med Chem
. 2009 Nov;
18(1):190-201.
PMID: 19932972
Piperidinyl diphenylsulfonyl sulfonamides are a novel class of molecules that have inhibitory binding affinity for sFRP-1. As a secreted protein sFRP-1 inhibits the function of the secreted Wnt glycoprotein. Therefore,...
9.
Bodine P, Stauffer B, Ponce-de-Leon H, Bhat R, Mangine A, Seestaller-Wehr L, et al.
Bone
. 2009 Mar;
44(6):1063-8.
PMID: 19254787
Canonical Wnt signaling has been demonstrated to increase bone formation, and Wnt pathway components are being pursued as potential drug targets for osteoporosis and other metabolic bone diseases. Deletion of...
10.
Moore W, Kern J, Bhat R, Commons T, Fukayama S, Goljer I, et al.
J Med Chem
. 2008 Dec;
52(1):105-16.
PMID: 19072540
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway...