Keith E Mostov
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Explore the profile of Keith E Mostov including associated specialties, affiliations and a list of published articles.
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71
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4707
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Recent Articles
11.
Gao L, Yang Z, Hiremath C, Zimmerman S, Long B, Brakeman P, et al.
Development
. 2017 Sep;
144(19):3511-3520.
PMID: 28860115
In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity is not known. We recently found that the F-actin-binding protein...
12.
Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity
Ruch T, Bryant D, Mostov K, Engel J
Mol Biol Cell
. 2016 Nov;
28(2):252-260.
PMID: 27881661
Pathogens can alter epithelial polarity by recruiting polarity proteins to the apical membrane, but how a change in protein localization is linked to polarity disruption is not clear. In this...
13.
Kwon S, Oh S, Nacke M, Mostov K, Lipschutz J
J Biol Chem
. 2016 Oct;
291(49):25462-25475.
PMID: 27765817
Exosomes, 40-150-nm extracellular vesicles, transport biological macromolecules that mediate intercellular communications. Although exosomes are known to originate from maturation of endosomes into multivesicular endosomes (also known as multivesicular bodies) with...
14.
Nedvetsky P, Zhao X, Mathivet T, Aspalter I, Stanchi F, Metzger R, et al.
Development
. 2016 Oct;
143(19):3582-3590.
PMID: 27702786
cAMP-dependent protein kinase A (PKA) is a ubiquitously expressed serine/threonine kinase that regulates a variety of cellular functions. Here, we demonstrate that endothelial PKA activity is essential for vascular development,...
15.
Kim M, Shewan A, Ewald A, Werb Z, Mostov K
J Cell Sci
. 2015 Oct;
128(23):4317-27.
PMID: 26483385
Tubulogenesis is fundamental to the development of many epithelial organs. Although lumen formation in cysts has received considerable attention, less is known about lumenogenesis in tubes. Here, we utilized tubulogenesis...
16.
Bryant D, Roignot J, Datta A, Overeem A, Kim M, Yu W, et al.
Dev Cell
. 2014 Oct;
31(2):171-87.
PMID: 25307480
The formation of epithelial tissues containing lumens requires not only the apical-basolateral polarization of cells, but also the coordinated orientation of this polarity such that the apical surfaces of neighboring...
17.
Nedvetsky P, Emmerson E, Finley J, Ettinger A, Cruz-Pacheco N, Prochazka J, et al.
Dev Cell
. 2014 Aug;
30(4):449-62.
PMID: 25158854
A fundamental question in development is how cells assemble to form a tubular network during organ formation. In glandular organs, tubulogenesis is a multistep process requiring coordinated proliferation, polarization and...
18.
Tran C, Eran Y, Ruch T, Bryant D, Datta A, Brakeman P, et al.
Cell Host Microbe
. 2014 May;
15(5):636-43.
PMID: 24832456
The mucosal epithelium consists of polarized cells with distinct apical and basolateral membranes that serve as functional and physical barriers to external pathogens. The apical surface of the epithelium constitutes...
19.
Kwon S, Liu K, Mostov K
Curr Biol
. 2014 Jan;
24(2):199-204.
PMID: 24412205
How cells communicate during development and regeneration is a critical question. One mechanism of intercellular communication is via exosomes, extracellular vesicles that originate by the fusion of multivesicular endosomes with...
20.
Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures
Cerruti B, Puliafito A, Shewan A, Yu W, Combes A, Little M, et al.
J Cell Biol
. 2013 Oct;
203(2):359-72.
PMID: 24145168
The growth of a well-formed epithelial structure is governed by mechanical constraints, cellular apico-basal polarity, and spatially controlled cell division. Here we compared the predictions of a mathematical model of...