Kazuya Miyashita
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Explore the profile of Kazuya Miyashita including associated specialties, affiliations and a list of published articles.
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68
Citations
907
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Recent Articles
1.
Kimura T, Miyashita K, Fukamachi I, Fukamachi K, Ogura K, Yokoyama E, et al.
J Lipid Res
. 2024 Apr;
65(4):100532.
PMID: 38608546
To support in vivo and in vitro studies of intravascular triglyceride metabolism in mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 and 31A5, were...
2.
Mattson N, Chan A, Miyashita K, Mukhaleva E, Chang W, Yang L, et al.
Nat Struct Mol Biol
. 2024 Feb;
31(3):465-475.
PMID: 38316881
The plasma membrane is enriched for receptors and signaling proteins that are accessible from the extracellular space for pharmacological intervention. Here we conducted a series of CRISPR screens using human...
3.
Kawarabayashi T, Nakamura T, Miyashita K, Segawa T, Fukamachi I, Sugawara T, et al.
J Alzheimers Dis
. 2023 Nov;
96(4):1623-1638.
PMID: 38007650
Background: The cerebrospinal fluid (CSF) levels of tau phosphorylated at threonine 217 (p217tau) or 181 (p181tau), and neurofilament light chain (NfL) are definite biomarkers of tauopathy and neurodegeneration in Alzheimer's...
4.
Song W, Beigneux A, Weston T, Chen K, Yang Y, Nguyen L, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(44):e2313825120.
PMID: 37871217
Lipoprotein lipase (LPL), the enzyme that carries out the lipolytic processing of triglyceride-rich lipoproteins (TRLs), is synthesized by adipocytes and myocytes and secreted into the interstitial spaces. The LPL is...
5.
Yang Y, Beigneux A, Song W, Nguyen L, Jung H, Tu Y, et al.
J Clin Invest
. 2023 Oct;
133(23).
PMID: 37824203
Why apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia has remained unclear, but we have suspected that the underlying cause is reduced amounts of lipoprotein lipase (LPL) in capillaries. By routine immunohistochemistry,...
6.
Tokita Y, Miyashita K, Nakajima K, Takahashi S, Tanaka A
Pract Lab Med
. 2023 Oct;
37:e00337.
PMID: 37781344
To investigate the regulation of soluble very low-density lipoprotein receptor (sVLDL-R), which is cleaved mostly from the extracellular domain of VLDL-R II, we generated two rat monoclonal antibodies (mAbs) against...
7.
Higashi T, Yoshida C, Hachiro Y, Nakata C, Takechi A, Yagi T, et al.
Bioorg Med Chem Lett
. 2023 Sep;
95:129471.
PMID: 37717362
To develop novel drugs for treating T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML) which are highly malignant hematological tumors, a series of analogs having a polyenylpyrrole structure...
8.
Miyashita K, Yagi T, Kagaya N, Takechi A, Nakata C, Kanda R, et al.
Cancer Sci
. 2023 Jul;
114(10):4032-4040.
PMID: 37522388
T-cell acute lymphoblastic leukemia (T-ALL) is one of the most frequently occurring cancers in children and is associated with a poor prognosis. Here, we performed large-scale screening of natural compound...
9.
Li M, Yang L, Chan A, Pokharel S, Liu Q, Mattson N, et al.
Adv Sci (Weinh)
. 2023 Apr;
10(17):e2206584.
PMID: 37075745
Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of...
10.
Taniguchi A, Miyashita K, Fukae S, Tanaka R, Nishida M, Kitayama T, et al.
Biochem Biophys Rep
. 2023 Feb;
33:101433.
PMID: 36798850
Ischemia-reperfusion injury (IRI) causes massive tissue damage. Renal IRI is the most common type of acute renal injury, and the defects caused by it may progress to chronic kidney disease...