Katsuhiro Togami
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Explore the profile of Katsuhiro Togami including associated specialties, affiliations and a list of published articles.
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38
Citations
601
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Recent Articles
1.
Booth C, Bouyssou J, Togami K, Armand O, Rivas H, Yan K, et al.
JCI Insight
. 2024 Nov;
9(24).
PMID: 39499902
MYB fusions are recurrently found in select cancers, including blastic plasmacytoid DC neoplasm (BPDCN), an acute leukemia with poor prognosis. They are markedly enriched in BPDCN compared with other blood...
2.
Griffin G, Booth C, Togami K, Chung S, Ssozi D, Verga J, et al.
Nature
. 2023 Jun;
618(7966):834-841.
PMID: 37286599
Tumours most often arise from progression of precursor clones within a single anatomical niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute leukaemia, or differentiate into...
3.
Togami K, Chung S, Madan V, Booth C, Kenyon C, Cabal-Hierro L, et al.
Cancer Discov
. 2021 Oct;
12(2):522-541.
PMID: 34615655
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in men than in women, but the...
4.
Nomburg J, Bullman S, Chung S, Togami K, Walker M, Griffin G, et al.
Blood Adv
. 2020 Mar;
4(6):1006-1011.
PMID: 32182365
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hematologic malignancy believed to originate from plasmacytoid dendritic cells (pDCs), the immune cells responsible for producing type 1 interferons during infection. Nearly...
5.
Cabal-Hierro L, van Galen P, Prado M, Higby K, Togami K, Mowery C, et al.
Nat Commun
. 2020 Mar;
11(1):1406.
PMID: 32179749
Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report that the chromatin accessibility...
6.
Togami K, Pastika T, Stephansky J, Ghandi M, Christie A, Jones K, et al.
J Clin Invest
. 2019 Aug;
129(11):5005-5019.
PMID: 31437130
The interleukin-3 receptor α subunit, CD123, is expressed in many hematologic malignancies including acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). Tagraxofusp (SL-401) is a CD123-targeted therapy...
7.
Montero J, Stephansky J, Cai T, Griffin G, Cabal-Hierro L, Togami K, et al.
Cancer Discov
. 2016 Dec;
7(2):156-164.
PMID: 27986708
Significance: Therapy for BPDCN is inadequate, and survival in patients with the disease is poor. We used primary tumor cell functional profiling to predict BCL2 antagonist sensitivity as a common...
8.
Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, et al.
J Biochem
. 2015 Nov;
159(1):17-25.
PMID: 26590301
Recent progress in high-speed sequencing technology has revealed that tumors harbor novel mutations in a variety of genes including those for molecules involved in epigenetics and splicing, some of which...
9.
Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata K, et al.
Exp Hematol
. 2014 Dec;
43(4):300-8.e1.
PMID: 25534203
Two types of CCAAT-enhancer-binding protein α (C/EBPα) mutants are found in acute myeloid leukemia (AML) patients: N-terminal frame-shift mutants (C/EBPα-N(m)) generating p30 as a dominant form and C-terminal basic leucine...
10.
Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, et al.
Proc Jpn Acad Ser B Phys Biol Sci
. 2014 Dec;
90(10):389-404.
PMID: 25504228
Myeloid malignancies consist of acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and myeloproliferative neoplasm (MPN). The latter two diseases have preleukemic features and frequently evolve to AML. As with solid...