Katrina M Lappin
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Explore the profile of Katrina M Lappin including associated specialties, affiliations and a list of published articles.
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7
Citations
49
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Recent Articles
1.
Piccin A, Allameddine A, Spizzo G, Lappin K, Prati D
J Clin Med
. 2024 Sep;
13(18).
PMID: 39336845
The recent COVID-19 pandemic has significantly challenged blood transfusion services (BTS) for providing blood products and for keeping blood supplies available. The possibility that a similar pandemic event may occur...
2.
Ali A, Cairns L, Clarke K, Blayney J, Lappin K, Mills K
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982791
Paediatric acute myeloid leukaemia (AML) continues to present treatment challenges, as no "standard approach" exists to treat those young patients reliably and safely. Combination therapies could become a viable treatment...
3.
Lappin K, Barros E, Jhujh S, Irwin G, McMillan H, Liberante F, et al.
Cancer Res
. 2022 Jan;
82(5):819-830.
PMID: 35027467
Significance: The cancer-associated SF3B1K700E mutation induces DNA damage via generation of genotoxic R-loops and stalled replication forks, defective homologous recombination, and increased replication fork degradation, which can be targeted with...
4.
Cairns L, Lappin K, Mutch A, Ali A, Matchett K, Mills K
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576326
Paediatric acute myeloid leukaemia (AML) is a heterogeneous disease characterised by the malignant transformation of myeloid precursor cells with impaired differentiation. Standard therapy for paediatric AML has remained largely unchanged...
5.
Lappin K, Mills K, Lappin T
Stem Cells Transl Med
. 2021 Jan;
10(6):836-843.
PMID: 33475252
Bone homeostasis and hematopoiesis are irrevocably linked in the hypoxic environment of the bone marrow. Erythropoietin (Epo) regulates erythropoiesis by binding to its receptor, Epor, on erythroid progenitor cells. The...
6.
Lappin K, Davis L, Matchett K, Ge Y, Mills K, Blayney J
Sci Rep
. 2020 Oct;
10(1):18514.
PMID: 33116257
Paediatric acute myeloid leukaemia (AML) is a heterogeneous disease characterised by genetics and morphology. The introduction of intensive chemotherapy treatments together with patient stratification and supportive therapy has resulted in...
7.
Smith J, Lappin K, Craig S, Liberante F, Crean C, McDade S, et al.
J Transl Med
. 2020 Sep;
18(1):339.
PMID: 32883299
Background: The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic...