Katia Georgopoulos
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Explore the profile of Katia Georgopoulos including associated specialties, affiliations and a list of published articles.
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65
Citations
2545
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Recent Articles
1.
Ichiyama K, Long J, Kobayashi Y, Horita Y, Kinoshita T, Nakamura Y, et al.
Immunity
. 2024 Aug;
57(9):2043-2060.e10.
PMID: 39111316
The master transcription factor of regulatory T (Treg) cells, forkhead box protein P3 (Foxp3), controls Treg cell function by targeting certain genes for activation or repression, but the specific mechanisms...
2.
Kilic A, Halu A, De Marzio M, Maiorino E, Duvall M, Bruggemann T, et al.
Elife
. 2024 Apr;
12.
PMID: 38567749
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do...
3.
Hu Y, Figueroa D, Zhang Z, Veselits M, Bhattacharyya S, Kashiwagi M, et al.
Cell
. 2023 Nov;
186(24):5269-5289.e22.
PMID: 37995656
A generic level of chromatin organization generated by the interplay between cohesin and CTCF suffices to limit promiscuous interactions between regulatory elements, but a lineage-specific chromatin assembly that supersedes these...
4.
Mandal M, Maienschein-Cline M, Hu Y, Mohsin A, Veselits M, Wright N, et al.
Nat Immunol
. 2023 Nov;
25(1):129-141.
PMID: 37985858
Lymphocyte development consists of sequential and mutually exclusive cell states of proliferative selection and antigen receptor gene recombination. Transitions between each state require large, coordinated changes in epigenetic landscapes and...
5.
OConnor K, Liu T, Kim S, Briseno C, Georgopoulos K, Murphy T, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(35):e2220853120.
PMID: 37607223
Ly6C monocytes are a myeloid subset that specializes in the surveillance of vascular endothelium. Ly6C monocytes have been shown to derive from Ly6C monocytes. NOTCH2 signaling has been implicated as...
6.
Kashiwagi M, Figueroa D, Ay F, Morgan B, Georgopoulos K
Nat Immunol
. 2022 Nov;
23(11):1628-1643.
PMID: 36316479
T cell differentiation requires Notch1 signaling. In the present study, we show that an enhancer upstream of Notch1 active in double-negative (DN) mouse thymocytes is responsible for raising Notch1 signaling...
7.
Jimenez-Andrade Y, Hillette K, Yoshida T, Kashiwagi M, Choo M, Liang Y, et al.
J Immunol
. 2022 May;
208(12):2613-2621.
PMID: 35623662
Keratinocytes, the epithelial cells of the skin, reprogram their gene expression and produce immune effector molecules when exposed to environmental and endogenous triggers of inflammation. It remains unclear how keratinocytes...
8.
Chu Z, Gu L, Hu Y, Zhang X, Li M, Chen J, et al.
Nat Commun
. 2022 Apr;
13(1):1859.
PMID: 35388001
The cohesin complex participates in the organization of 3D genome through generating and maintaining DNA loops. Stromal antigen 2 (STAG2), a core subunit of the cohesin complex, is frequently mutated...
9.
Thomas K, Allenspach E, Camp N, Wray-Dutra M, Khim S, Zielinska-Kwiatkowska A, et al.
Leukemia
. 2021 Jul;
36(1):42-57.
PMID: 34193976
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype of B-ALL often associated with genetic variants that alter cytokine receptor signaling, including mutations in the interleukin-7 receptor (IL7R)....
10.
Lazarian G, Yin S, Ten Hacken E, Sewastianik T, Uduman M, Font-Tello A, et al.
Cancer Cell
. 2021 Mar;
39(3):380-393.e8.
PMID: 33689703
Hotspot mutation of IKZF3 (IKZF3-L162R) has been identified as a putative driver of chronic lymphocytic leukemia (CLL), but its function remains unknown. Here, we demonstrate its driving role in CLL...