Kathryn M Lenz
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Explore the profile of Kathryn M Lenz including associated specialties, affiliations and a list of published articles.
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30
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1510
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Recent Articles
1.
Gilfarb R, Ranade S, Dybas E, Biddle A, Stewart M, Rajesh A, et al.
Brain Behav Immun
. 2025 Feb;
PMID: 39978694
Adolescence is a period of protracted neurodevelopment, during which the prefrontal cortex (PFC) undergoes significant remodeling. Microglia are integral to neurodevelopment and are sensitive to gonadal hormones, which increase during...
2.
Dye C, Webb A, Fankhauser M, Singleton J, Kalathil A, Ringland A, et al.
Brain Behav Immun
. 2024 Nov;
124:264-279.
PMID: 39612963
7 % of pregnant people use opioids. Opioid use during pregnancy can negatively impact maternal and offspring health. Medications for opioid use disorder (MOUD), commonly buprenorphine, are the recommended treatment...
3.
Smail M, Lenz K
Neuropharmacology
. 2024 Jul;
258:110084.
PMID: 39025401
Microglia play numerous important roles in brain development. From early embryonic stages through adolescence, these immune cells influence neuronal genesis and maturation, guide connectivity, and shape brain circuits. They also...
4.
Breach M, Akouri H, Costantine S, Dodson C, McGovern N, Lenz K
Horm Behav
. 2023 Sep;
157:105427.
PMID: 37743114
Prenatal exposure to inflammation via maternal infection, allergy, or autoimmunity increases one's risk for developing neurodevelopmental and psychiatric disorders. Many of these disorders are associated with altered social behavior, yet...
5.
Dye C, Franceschelli D, Leuner B, Lenz K
Neuropsychopharmacology
. 2023 Jun;
48(13):1869-1877.
PMID: 37330580
The peripartum period is accompanied by peripheral immune alterations to promote a successful pregnancy. We and others have also demonstrated significant neuroimmune changes that emerge during late pregnancy and persist...
6.
Breach M, Lenz K
Curr Top Behav Neurosci
. 2022 Apr;
62:165-206.
PMID: 35435643
Sex differences are prominent defining features of neurodevelopmental disorders. Understanding the sex biases in these disorders can shed light on mechanisms leading to relative risk and resilience for the disorders,...
7.
Breach M, Dye C, Galan A, Lenz K
Brain Behav Immun
. 2022 Mar;
102:279-291.
PMID: 35245680
Allergic inflammation during pregnancy increases risk for a diagnosis of neurodevelopmental disorders such as Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) in the offspring. Previously, we found a...
8.
Dye C, Lenz K, Leuner B
Front Glob Womens Health
. 2022 Feb;
2:758748.
PMID: 35224544
The postpartum period is a time associated with high rates of depression and anxiety as well as greater risk for psychosis in some women. A growing number of studies point...
9.
Breach M, Dye C, Joshi A, Platko S, Gilfarb R, Krug A, et al.
Brain Behav Immun
. 2021 Apr;
95:269-286.
PMID: 33798637
Maternal systemic inflammation increases risk for neurodevelopmental disorders like autism, ADHD, and schizophrenia in offspring. Notably, these disorders are male-biased. Studies have implicated immune system dysfunction in the etiology of...
10.
Nelson L, Peketi P, Lenz K
Neuroscience
. 2020 Nov;
453:237-255.
PMID: 33129890
Microglia, the innate immune cells of the brain, regulate brain development through many processes such as synaptic pruning, supporting cell genesis and phagocytosing living and dying cells. There are sex...