Karl Willert
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Explore the profile of Karl Willert including associated specialties, affiliations and a list of published articles.
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48
Citations
3876
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Recent Articles
11.
Grainger S, Willert K
Wiley Interdiscip Rev Syst Biol Med
. 2018 Mar;
10(5):e1422.
PMID: 29600540
The Wnt signaling pathway is a highly conserved system that regulates complex biological processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to break symmetry and...
12.
Grainger S, Traver D, Willert K
Prog Mol Biol Transl Sci
. 2018 Feb;
153:321-341.
PMID: 29389522
Leukemia and lymphoma are a wide encompassing term for a diverse set of blood malignancies that affect people of all ages and result in approximately 23,000 deaths in the United...
13.
Richter J, Stanley E, Ng E, Elefanty A, Traver D, Willert K
Genes (Basel)
. 2018 Feb;
9(2).
PMID: 29382179
Hematopoietic stem cells (HSCs) differentiate into all cell types of the blood and can be used therapeutically to treat hematopoietic cancers and disorders. Despite decades of research, it is not...
14.
The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
Huggins I, Bos T, Gaylord O, Jessen C, Lonquich B, Puranen A, et al.
Nat Commun
. 2017 Oct;
8(1):1034.
PMID: 29044119
The WNT/β-catenin signaling pathway is a prominent player in many developmental processes, including gastrulation, anterior-posterior axis specification, organ and tissue development, and homeostasis. Here, we use human pluripotent stem cells...
15.
Brafman D, Willert K
Dev Neurobiol
. 2017 Aug;
77(11):1239-1259.
PMID: 28799266
The vertebrate central nervous system (CNS) is comprised of vast number of distinct cell types arranged in a highly organized manner. This high degree of complexity is achieved by cellular...
16.
Rodvold J, Chiu K, Hiramatsu N, Nussbacher J, Galimberti V, Mahadevan N, et al.
Sci Signal
. 2017 Jun;
10(482).
PMID: 28588081
Increased protein translation in cells and various factors in the tumor microenvironment can induce endoplasmic reticulum (ER) stress, which initiates the unfolded protein response (UPR). We have previously reported that...
17.
Richter J, Traver D, Willert K
Crit Rev Biochem Mol Biol
. 2017 May;
52(4):414-424.
PMID: 28508727
No abstract available.
18.
Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, et al.
Dev Cell
. 2017 Mar;
40(5):439-452.e4.
PMID: 28292423
Polarization of node cells along the anterior-posterior axis of mouse embryos is responsible for left-right symmetry breaking. How node cells become polarized has remained unknown, however. Wnt5a and Wnt5b are...
19.
Grainger S, Lonquich B, Oon C, Nguyen N, Willert K, Traver D
Zebrafish
. 2016 Nov;
14(4):383-386.
PMID: 27829120
Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has been applied to edit genomes in a wide variety of model systems. Although this process can be quite efficient, editing at precise...
20.
Grainger S, Richter J, Palazon R, Pouget C, Lonquich B, Wirth S, et al.
Cell Rep
. 2016 Nov;
17(6):1595-1606.
PMID: 27806298
All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells (HSPCs). However, the developmental cues regulating HSPC ontogeny are incompletely understood. In particular, the...