Karl E Duderstadt
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Explore the profile of Karl E Duderstadt including associated specialties, affiliations and a list of published articles.
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795
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Recent Articles
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Scherr M, Safaric B, Duderstadt K
Bioessays
. 2017 Dec;
40(2).
PMID: 29282758
The astonishing efficiency and accuracy of DNA replication has long suggested that refined rules enforce a single highly reproducible sequence of molecular events during the process. This view was solidified...
13.
Lewis J, Spenkelink L, Jergic S, Wood E, Monachino E, Horan N, et al.
Elife
. 2017 Apr;
6.
PMID: 28432790
The DNA replication machinery has been used as a road map to uncover design rules that enable DNA duplication with high efficiency and fidelity. Although the enzymatic activities of the...
14.
Duderstadt K, Geertsema H, Stratmann S, Punter C, Kulczyk A, Richardson C, et al.
Mol Cell
. 2016 Nov;
64(6):1035-1047.
PMID: 27889453
The molecular machinery responsible for DNA replication, the replisome, must efficiently coordinate DNA unwinding with priming and synthesis to complete duplication of both strands. Due to the anti-parallel nature of...
15.
Aberg C, Duderstadt K, van Oijen A
Nucleic Acids Res
. 2016 Apr;
44(10):4846-54.
PMID: 27112565
Multi-component biological machines, comprising individual proteins with specialized functions, perform a variety of essential processes in cells. Once assembled, most such complexes are considered very stable, retaining individual constituents as...
16.
Geertsema H, Duderstadt K, van Oijen A
Methods Mol Biol
. 2015 Apr;
1300:219-38.
PMID: 25916715
Replication of DNA requires the coordinated activity of a number of proteins within a multiprotein complex, the replisome. Recent advances in single-molecule techniques have enabled the observation of dynamic behavior...
17.
Duderstadt K, Reyes-Lamothe R, van Oijen A, Sherratt D
Cold Spring Harb Perspect Biol
. 2013 Jul;
6(1).
PMID: 23881939
The proliferation of all organisms depends on the coordination of enzymatic events within large multiprotein replisomes that duplicate chromosomes. Whereas the structure and function of many core replisome components have...
18.
Duderstadt K, Berger J
Curr Opin Struct Biol
. 2012 Dec;
23(1):144-53.
PMID: 23266000
ATP-dependent initiation factors help process replication origins and coordinate replisome assembly to control the onset of DNA synthesis. Although the specific properties and regulatory mechanisms of initiator proteins can vary...
19.
Duderstadt K, Chuang K, Berger J
Nature
. 2011 Oct;
478(7368):209-13.
PMID: 21964332
Many replication initiators form higher-order oligomers that process host replication origins to promote replisome formation. In addition to dedicated duplex-DNA-binding domains, cellular initiators possess AAA+ (ATPases associated with various cellular...
20.
Duderstadt K, Mott M, Crisona N, Chuang K, Yang H, Berger J
J Biol Chem
. 2010 Jul;
285(36):28229-39.
PMID: 20595381
The initiation of DNA replication requires the melting of chromosomal origins to provide a template for replisomal polymerases. In bacteria, the DnaA initiator plays a key role in this process,...