Karen R Jonscher
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Explore the profile of Karen R Jonscher including associated specialties, affiliations and a list of published articles.
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28
Citations
915
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Recent Articles
1.
Sugino K, Janssen R, McMahan R, Zimmerman C, Friedman J, Jonscher K
Nutrients
. 2024 Jun;
16(12).
PMID: 38931163
Maternal obesity and/or Western diet (WD) is associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in offspring, driven, in part, by the dysregulation of the early...
2.
Sugino K, Mandala A, Janssen R, Gurung S, Trammell M, Day M, et al.
Front Clin Diabetes Healthc
. 2023 Mar;
3.
PMID: 36935840
Maternal consumption of a high-fat, Western-style diet (WD) disrupts the maternal/infant microbiome and contributes to developmental programming of the immune system and nonalcoholic fatty liver disease (NAFLD) in the offspring....
3.
Zhang L, Jonscher K, Zhang Z, Xiong Y, Mueller R, Friedman J, et al.
Nat Commun
. 2022 Jun;
13(1):3551.
PMID: 35729161
The immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against pancreatic β cells, which greatly increases their risk for...
4.
Mandala A, Dobrinskikh E, Janssen R, Fiehn O, DAlessandro A, Friedman J, et al.
Int J Mol Sci
. 2022 Jun;
23(11).
PMID: 35682720
Maternal obesity and consumption of a high-fat diet significantly elevate risk for pediatric nonalcoholic fatty liver disease (NAFLD), affecting 10% of children in the US. Almost half of these children...
5.
Jonscher K, Chowanadisai W, Rucker R
Biomolecules
. 2021 Oct;
11(10).
PMID: 34680074
Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and lipotoxicity)....
6.
Jonscher K, Abrams J, Friedman J
J Cell Immunol
. 2021 Jan;
2(6):315-325.
PMID: 33426540
Pediatric nonalcoholic fatty liver disease (NAFLD) affects 1 in 10 children in the US, increases risk of cirrhosis and transplantation in early adulthood, and shortens lifespan, even after transplantation. Exposure...
7.
Jonscher K, Bruce K
Adv Exp Med Biol
. 2019 Mar;
1134:33-58.
PMID: 30919331
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disorders ranging from simple steatosis to steatosis with inflammation and fibrosis. NAFLD is currently the most prevalent chronic liver disease worldwide,...
8.
Friedman J, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen R, Soderborg T, et al.
Hepatol Commun
. 2018 Mar;
2(3):313-328.
PMID: 29507905
Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment , exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to...
9.
Bruce K, Jonscher K
Methods Mol Biol
. 2018 Jan;
1735:251-266.
PMID: 29380318
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide and is present in a third of the general population and the majority of...
10.
Blaber E, Pecaut M, Jonscher K
Int J Mol Sci
. 2017 Sep;
18(10).
PMID: 28953266
Increased oxidative stress is an unavoidable consequence of exposure to the space environment. Our previous studies showed that mice exposed to space for 13.5 days had decreased glutathione levels, suggesting...