Karen Newell-Litwa
Overview
Explore the profile of Karen Newell-Litwa including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
370
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Wilson E, Knudson W, Newell-Litwa K
Sci Rep
. 2020 Oct;
10(1):16459.
PMID: 33020512
Neurodevelopmental disorders present with synaptic alterations that disrupt the balance between excitatory and inhibitory signaling. For example, hyperexcitability of cortical neurons is associated with both epilepsy and autism spectrum disorders....
2.
Wilson E, Rudisill T, Kirk B, Johnson C, Kemper P, Newell-Litwa K
J Neurosci Res
. 2020 Jul;
98(11):2148-2165.
PMID: 32713041
Excitatory synapse formation begins in mid-fetal gestation. However, due to our inability to image fetal synaptogenesis, the initial formation of synapses remains understudied. The recent development of human fetal brain...
3.
Papariello A, Newell-Litwa K
Assay Drug Dev Technol
. 2019 May;
18(2):79-88.
PMID: 31090445
Human-derived neurons and brain organoids have revolutionized our ability to model brain development in a dish. In this review, we discuss the potential for human brain models to advance drug...
4.
Wilson E, Newell-Litwa K
Mol Biol Cell
. 2018 Nov;
29(24):2913-2921.
PMID: 30475098
Many brain disorders exhibit altered synapse formation in development or synapse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain...
5.
Martin-Vilchez S, Whitmore L, Asmussen H, Zareno J, Horwitz R, Newell-Litwa K
PLoS One
. 2017 Jan;
12(1):e0170464.
PMID: 28114311
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine...
6.
Hodges J, Newell-Litwa K, Asmussen H, Vicente-Manzanares M, Horwitz A
PLoS One
. 2011 Sep;
6(8):e24149.
PMID: 21887379
Dendritic spines in hippocampal neurons mature from a filopodia-like precursor into a mushroom-shape with an enlarged post-synaptic density (PSD) and serve as the primary post-synaptic location of the excitatory neurotransmission...
7.
Vicente-Manzanares M, Newell-Litwa K, Bachir A, Whitmore L, Horwitz A
J Cell Biol
. 2011 Apr;
193(2):381-96.
PMID: 21482721
Migratory front-back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during polarization, MIIA and MIIB coordinately promote localized...
8.
Newell-Litwa K, Chintala S, Jenkins S, Pare J, McGaha L, Smith Y, et al.
J Neurosci
. 2010 Jan;
30(3):820-31.
PMID: 20089890
Endosomal sorting mechanisms mediated by AP-3 and BLOC-1 are perturbed in Hermansky-Pudlak Syndrome, a human genetic condition characterized by albinism and prolonged bleeding (OMIM #203300). Additionally, mouse models defective in...
9.
Newell-Litwa K, Salazar G, Smith Y, Faundez V
Mol Biol Cell
. 2009 Jan;
20(5):1441-53.
PMID: 19144828
Neuronal lysosomes and their biogenesis mechanisms are primarily thought to clear metabolites and proteins whose abnormal accumulation leads to neurodegenerative disease pathology. However, it remains unknown whether lysosomal sorting mechanisms...
10.
Newell-Litwa K, Seong E, Burmeister M, Faundez V
J Cell Sci
. 2007 Feb;
120(Pt 4):531-41.
PMID: 17287392
Vesicles selectively exchange lipids, membrane proteins and luminal contents between organelles along the exocytic and endocytic routes. The repertoire of membrane proteins present in these vesicles is crucial for their...