Karen L Edelblum
Overview
Explore the profile of Karen L Edelblum including associated specialties, affiliations and a list of published articles.
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43
Citations
1193
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Recent Articles
11.
Lei X, Ketelut-Carneiro N, Shmuel-Galia L, Xu W, Wilson R, Vierbuchen T, et al.
J Exp Med
. 2022 Jul;
219(8).
PMID: 35792863
Hepatocyte nuclear factor 4 α (HNF4A) is a highly conserved nuclear receptor that has been associated with ulcerative colitis. In mice, HNF4A is indispensable for the maintenance of intestinal homeostasis,...
12.
Jia L, Wu G, Alonso S, Zhao C, Lemenze A, Lam Y, et al.
Mucosal Immunol
. 2022 May;
15(4):772-782.
PMID: 35589986
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IELs) serve as a first line of defense against luminal microbes. Although the presence of an intact microbiota is dispensable for...
13.
Krzyzanowska A, Haynes Ii R, Kovalovsky D, Lin H, Osorio L, Edelblum K, et al.
Sci Immunol
. 2022 May;
7(71):eabf3717.
PMID: 35522722
The expression of BTB-ZF transcription factors such as ThPOK in CD4 T cells, Bcl6 in T follicular helper cells, and PLZF in natural killer T cells defines the fundamental nature...
14.
Hu M, Golovchenko N, Burns G, Nair P, Kelly 4th T, Agos J, et al.
Gastroenterology
. 2021 Dec;
162(3):877-889.e7.
PMID: 34861219
Background & Aims: Excessive shedding of apoptotic enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. Based on their cytolytic capacity and...
15.
Edelblum K
Nat Rev Gastroenterol Hepatol
. 2021 Jul;
18(9):591.
PMID: 34253902
No abstract available.
16.
Fischer M, Golovchenko N, Edelblum K
Immunol Rev
. 2020 Aug;
298(1):165-180.
PMID: 32845516
γδ T cells are found in highest numbers at barrier surfaces throughout the body, including the skin, intestine, lung, gingiva, and uterus. Under homeostatic conditions, γδ T cells provide immune...
17.
Kuo W, Shen L, Zuo L, Shashikanth N, Ong M, Wu L, et al.
Gastroenterology
. 2019 Aug;
157(5):1323-1337.
PMID: 31401143
Background & Aims: Epithelial tight junctions are compromised in gastrointestinal disease. Processes that contribute to the resulting barrier loss include endocytic occludin removal from the tight junction and reduced occludin...
18.
Jia L, Edelblum K
J Vis Exp
. 2019 Jul;
(148).
PMID: 31282900
Intraepithelial lymphocytes expressing γδ T cell receptor (γδ IEL) play a key role in immune surveillance of the intestinal epithelium. Due in part to the lack of a definitive ligand...
19.
Edelblum K
Cell Mol Gastroenterol Hepatol
. 2019 Apr;
8(1):149-150.
PMID: 31029561
No abstract available.
20.
Nalle S, Zuo L, Ong M, Singh G, Worthylake A, Choi W, et al.
J Clin Invest
. 2019 Jan;
129(2):902-914.
PMID: 30667372
Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation (HSCT) that affects multiple organs. GVHD-associated intestinal damage can be separated into two distinct phases, initiation and propagation, which...