Jeremy A Goettel
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Explore the profile of Jeremy A Goettel including associated specialties, affiliations and a list of published articles.
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48
Citations
1653
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Recent Articles
1.
Li J, Jacobse J, Pilat J, Kaur H, Gu W, Kang S, et al.
Mucosal Immunol
. 2025 Feb;
PMID: 39988202
Interleukin-10 (IL-10) is an immunomodulatory cytokine critical for intestinal immune homeostasis. IL-10 is produced by various immune cells but IL-10 receptor signaling in intestinal CXCR1 mononuclear phagocytes is necessary to...
2.
Spencer P, Wang J, Smith E, Spiga L, Simmons A, Kim T, et al.
bioRxiv
. 2025 Jan;
PMID: 39803424
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions and not others remains unclear. We use a TNF-overexpressing Crohn's disease...
3.
Li J, Simmons A, Hawkins C, Chiron S, Ramirez-Solano M, Tasneem N, et al.
Nat Commun
. 2024 Aug;
15(1):7204.
PMID: 39169060
Crohn's disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify a...
4.
Short S, Brown R, Chen Z, Pilat J, McElligott B, Meenderink L, et al.
Cell Death Differ
. 2024 Jul;
31(9):1170-1183.
PMID: 39048708
Undifferentiated intestinal stem cells (ISCs) are crucial for maintaining homeostasis and resolving injury. Lgr5+ cells in the crypt base constantly divide, pushing daughter cells upward along the crypt axis where...
5.
Hiremath G, Choksi Y, Correa H, Jacobse J, Das S, Ma S, et al.
Allergy
. 2024 Jul;
79(10):2798-2811.
PMID: 38993131
Background: A combination of proton-pump inhibitors (PPI) and topical steroids (TS) is used to treat children with eosinophilic esophagitis (EoE). However, a subset of children do not respond to this...
6.
Diaz D, Bergdorf K, Loberg M, Phifer C, Xu G, Sheng Q, et al.
Endocrine
. 2024 May;
86(1):114-118.
PMID: 38806891
Background: Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy that has consistently shown Wnt/β-catenin (canonical) signaling activation in various study populations. There are currently no targetable treatments for BRAF-wildtype...
7.
Jacobse J, Pilat J, Li J, Brown R, Kwag A, Buendia M, et al.
Front Oncol
. 2024 Feb;
13:1276743.
PMID: 38375204
Introduction: The pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell...
8.
Rajagopala S, Shilts M, Correa H, Das S, Choksi Y, Jacobse J, et al.
J Pediatr Pharmacol Ther
. 2023 Dec;
28(6):504-508.
PMID: 38130344
Objective: Proton pump inhibitors (PPIs) are commonly used to manage children with upper gastrointestinal symptoms and without a formal diagnosis. We investigated the effect of PPIs on esophageal mucosal transcriptome...
9.
Latour Y, McNamara K, Allaman M, Barry D, Smith T, Asim M, et al.
Sci Rep
. 2023 Dec;
13(1):22368.
PMID: 38102166
The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major contributor to disease pathogenesis. Integrins are...
10.
Kaur H, Ali S, Short S, Williams C, Goettel J, Washington M, et al.
Gut Microbes
. 2023 Oct;
15(2):2264456.
PMID: 37815528
Several probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions....