Kalyan C Tirupula
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Explore the profile of Kalyan C Tirupula including associated specialties, affiliations and a list of published articles.
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14
Citations
455
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Recent Articles
1.
Mitchell J, Yanamala N, Tan Y, Gardner E, Tirupula K, Balem F, et al.
Photochem Photobiol
. 2018 Dec;
95(3):787-802.
PMID: 30582615
The chlorophyll-derivative chlorin e6 (Ce6) identified in the retinas of deep-sea ocean fish is proposed to play a functional role in red bioluminescence detection. Fluorescence and H NMR spectroscopy studies...
2.
Tirupula K, Zhang D, Osbourne A, Chatterjee A, Desnoyer R, Willard B, et al.
PLoS One
. 2015 Oct;
10(10):e0140872.
PMID: 26484771
Propagation of signals from G protein-coupled receptors (GPCRs) in cells is primarily mediated by protein-protein interactions. MAS is a GPCR that was initially discovered as an oncogene and is now...
3.
Tirupula K, Ithychanda S, Mohan M, Naga Prasad S, Qin J, Karnik S
Biochemistry
. 2015 Oct;
54(44):6673-83.
PMID: 26460884
Although interaction of a few G protein-coupled receptors (GPCRs) with Filamin A, a key actin cross-linking and biomechanical signal transducer protein, has been observed, a comprehensive structure-function analysis of this...
4.
Karnik S, Unal H, Kemp J, Tirupula K, Eguchi S, Vanderheyden P, et al.
Pharmacol Rev
. 2015 Aug;
67(4):754-819.
PMID: 26315714
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states. Nearly half of humanity today would...
5.
Zhang H, Unal H, Gati C, Han G, Liu W, Zatsepin N, et al.
Cell
. 2015 Apr;
161(4):833-44.
PMID: 25913193
Angiotensin II type 1 receptor (AT(1)R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance. Although several anti-hypertensive drugs have been developed as AT(1)R...
6.
A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A
Ithychanda S, Fang X, Mohan M, Zhu L, Tirupula K, Naga Prasad S, et al.
J Biol Chem
. 2015 Feb;
290(13):8527-38.
PMID: 25666618
Protein phosphorylation mediates essentially all aspects of cellular life. In humans, this is achieved by ∼500 kinases, each recognizing a specific consensus motif (CM) in the substrates. The majority of...
7.
Tirupula K, Desnoyer R, Speth R, Karnik S
PLoS One
. 2014 Jul;
9(7):e103520.
PMID: 25068582
MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on...
8.
Isin B, Tirupula K, Oltvai Z, Klein-Seetharaman J, Bahar I
Methods Mol Biol
. 2012 Sep;
914:285-317.
PMID: 22976035
Identifying the functional motions of membrane proteins is difficult because they range from large-scale collective dynamics to local small atomic fluctuations at different timescales that are difficult to measure experimentally...
9.
Moitra S, Tirupula K, Klein-Seetharaman J, Langmead C
BMC Biophys
. 2012 Jul;
5:13.
PMID: 22748306
Background: G protein coupled receptors (GPCRs) are seven helical transmembrane proteins that function as signal transducers. They bind ligands in their extracellular and transmembrane regions and activate cognate G proteins...
10.
Dutta A, Tirupula K, Alexiev U, Klein-Seetharaman J
Biochemistry
. 2010 Jun;
49(30):6317-28.
PMID: 20575534
Little is known about the general folding mechanisms of helical membrane proteins. Unfolded, i.e., non-native states, in particular, have not yet been characterized in detail. Here, we establish conditions under...