Russell Desnoyer
Overview
Explore the profile of Russell Desnoyer including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
457
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0
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Recent Articles
1.
Jara Z, Harford T, Singh K, Desnoyer R, Kumar A, Srinivasan D, et al.
Hypertension
. 2022 Nov;
80(2):385-402.
PMID: 36440576
Background: Aortic aneurysm (AA) is a "silent killer" human disease with no effective treatment. Although the therapeutic potential of various pharmacological agents have been evaluated, there are no reports of...
2.
Singh K, Jara Z, Harford T, Saha P, Pardhi T, Desnoyer R, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34380734
While orthosteric ligands of the angiotensin II (AngII) type 1 receptor (AT1R) are available for clinical and research applications, allosteric ligands are not known for this important G protein-coupled receptor...
3.
Jara Z, Singh K, Unal H, Desnoyer R, Yokota R, Pesquero J, et al.
Methods Cell Biol
. 2019 Jan;
149:215-238.
PMID: 30616822
Maintenance of normal blood pressure under conditions of drug treatment is a measure of system-wide neuro-hormonal controls and electrolyte/fluid volume homeostasis in the body. With increased interest in designing and...
4.
Singh K, Unal H, Desnoyer R, Karnik S
J Chem Inf Model
. 2019 Jan;
59(1):373-385.
PMID: 30608150
We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation generated conformational ensembles reveal propagation of structural changes through key...
5.
Chatterjee A, Barnard J, Moravec C, Desnoyer R, Tirupula K, Karnik S
PLoS One
. 2017 Dec;
12(12):e0190217.
PMID: 29287092
Perspectives on whether the functions of MAS, a G protein-coupled receptor, are beneficial or deleterious in the heart remain controversial. MAS gene knockout reduces coronary vasodilatation leading to ischemic injury....
6.
Singh K, Unal H, Desnoyer R, Karnik S
J Chem Inf Model
. 2017 Dec;
58(1):182-193.
PMID: 29195045
Crystal structures of the human angiotensin II type 1 receptor (ATR) complex with the antihypertensive agent ZD7155 (PDB id: 4YAY ) and the blood pressure medication Benicar (PDB id: 4ZUD...
7.
Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan Z, Yong S, et al.
PLoS One
. 2016 May;
11(5):e0155198.
PMID: 27144543
[This corrects the article DOI: 10.1371/journal.pone.0052689.].
8.
Zhang H, Unal H, Desnoyer R, Han G, Patel N, Katritch V, et al.
J Biol Chem
. 2015 Oct;
290(49):29127-39.
PMID: 26420482
Angiotensin II type 1 receptor (AT1R) is the primary blood pressure regulator. AT1R blockers (ARBs) have been widely used in clinical settings as anti-hypertensive drugs and share a similar chemical...
9.
Zhang H, Unal H, Gati C, Han G, Liu W, Zatsepin N, et al.
Cell
. 2015 Apr;
161(4):833-44.
PMID: 25913193
Angiotensin II type 1 receptor (AT(1)R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance. Although several anti-hypertensive drugs have been developed as AT(1)R...
10.
Tirupula K, Desnoyer R, Speth R, Karnik S
PLoS One
. 2014 Jul;
9(7):e103520.
PMID: 25068582
MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on...