Kaitlin J Basham
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Explore the profile of Kaitlin J Basham including associated specialties, affiliations and a list of published articles.
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14
Citations
132
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Recent Articles
1.
Gorelick D, Gertz J, Basham K, Trevino L
J Endocr Soc
. 2024 Nov;
8(12):bvae191.
PMID: 39564580
Nuclear receptors are important in normal physiology and disease. Physicians and scientists who study nuclear receptors organize and attend conferences and symposia devoted to foundational and translational nuclear receptor research,...
2.
Borges K, Little 3rd D, de Almeida Magalhaes T, Ribeiro C, Dumontet T, Lapensee C, et al.
bioRxiv
. 2024 Sep;
PMID: 39229119
The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin...
3.
Fu R, Walters K, Kaufman M, Koc K, Baldwin A, Clay M, et al.
J Endocr Soc
. 2023 Nov;
7(12):bvad131.
PMID: 37953901
The human adrenal gland consists of concentrically organized, functionally distinct regions responsible for hormone production. Dysregulation of adrenocortical cell differentiation alters the proportion and organization of the functional zones of...
4.
Warde K, Smith L, Basham K
J Endocr Soc
. 2023 Aug;
7(9):bvad097.
PMID: 37564884
Aging is characterized by a gradual decline in physiological function. This process affects all organs including the adrenal cortex, which normally functions to produce essential steroid hormones including mineralocorticoids, glucocorticoids,...
5.
Penny M, Lerario A, Basham K, Chukkapalli S, Mohan D, Lapensee C, et al.
Cancers (Basel)
. 2023 Jul;
15(14).
PMID: 37509222
Adrenocortical carcinoma (ACC) is a rare but highly aggressive cancer with limited treatment options and poor survival for patients with advanced disease. An improved understanding of the transcriptional programs engaged...
6.
Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner
Warde K, Smith L, Liu L, Stubben C, Lohman B, Willett P, et al.
Nat Aging
. 2023 May;
3(7):846-865.
PMID: 37231196
Aging markedly increases cancer risk, yet our mechanistic understanding of how aging influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an inhibitor of Wnt signaling...
7.
Hahn A, Siddiqui B, Leo J, Dondossola E, Basham K, Miranti C, et al.
Endocrinology
. 2023 May;
164(6).
PMID: 37192413
Given the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-targeted therapies have been the backbone of prostate cancer treatment for over 50 years. New data...
8.
Leo J, Dondossola E, Basham K, Wilson N, Alhalabi O, Gao J, et al.
Endocrinology
. 2023 May;
164(6).
PMID: 37154098
The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include...
9.
Hammer G, Basham K
Mol Cell Endocrinol
. 2020 Oct;
519:111043.
PMID: 33058950
The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury....
10.
Basham K, Rodriguez S, Turcu A, Lerario A, Logan C, Rysztak M, et al.
Genes Dev
. 2019 Jan;
33(3-4):209-220.
PMID: 30692207
Spatiotemporal control of Wnt signaling is essential for the development and homeostasis of many tissues. The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and RNF43 (ring finger...