Ryan E Looper
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Explore the profile of Ryan E Looper including associated specialties, affiliations and a list of published articles.
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45
Citations
1214
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Recent Articles
1.
Nelli M, Cantrell R, Looper R
J Org Chem
. 2023 Oct;
88(22):15975-15982.
PMID: 37890169
Strategies to access the 1,4-diazepindiones heterocyclic core of the TAN-1057 family of natural products revealed a successful gold-catalyzed hydroamination of yneamide tethered amines. The precursor amino-yneamides are derived from easily...
2.
Rawson K, Neuberger T, Smith T, Bell I, Looper R, Sebahar P, et al.
Biofilm
. 2023 Jul;
6:100142.
PMID: 37484784
Implementation of negative pressure wound therapy (NPWT) as a standard of care has proven efficacious in reducing both the healing time and likelihood of nosocomial infection among pressure ulcers and...
3.
Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, et al.
Cancer Cell
. 2022 Aug;
40(9):939-956.e16.
PMID: 35985343
Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia, they seem to be less active in aggressive...
4.
Rawson K, Neuberger T, Smith T, Kanna Reddy H, Haussener T, Sebahar P, et al.
J Biomed Mater Res B Appl Biomater
. 2022 Feb;
110(8):1780-1788.
PMID: 35213779
Negative-pressure wound therapy (NPWT) is commonly utilized to treat traumatic injuries sustained on the modern battlefield. However, NPWT has failed to decrease the incidence of deep tissue infections experienced by...
5.
Looper R, Boger D, Silver L
Acc Chem Res
. 2021 Jul;
54(13):2785-2787.
PMID: 34225457
No abstract available.
6.
Nelli M, Heitmeier K, Looper R
Acc Chem Res
. 2021 Jun;
54(13):2798-2811.
PMID: 34152729
Without question, natural products have provided the lion share of leads, if not drugs themselves, for the treatment of bacterial infections. The bacterial arms race, fueled by selection and survival...
7.
Williams D, Kawaguchi B, Taylor N, Allyn G, Badham M, Rogers J, et al.
Biofilm
. 2021 Jan;
2:100032.
PMID: 33447817
Wounds complicated by biofilms challenge even the best clinical care and can delay a return to duty for service members. A major component of treatment in wounded warriors includes infected...
8.
Miller M, Rogers J, Badham M, Cadenas L, Brightwell E, Adams J, et al.
PLoS One
. 2020 Oct;
15(10):e0234832.
PMID: 33075071
Biofilm-impaired tissue is a significant factor in chronic wounds such as diabetic foot ulcers. Most, if not all, anti-biotics in clinical use have been optimized against planktonic phenotypes. In this...
9.
Serrano C, Kanna Reddy H, Eiler D, Koch M, Tresco B, Barrows L, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(28):11330-11333.
PMID: 32342623
In search of new anti-tuberculars compatible with anti-retroviral therapy we re-identified amicetin as a lead compound. Amicetin's binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously...
10.
A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid
Paladugu S, James C, Looper R
Org Lett
. 2019 Sep;
21(19):7999-8002.
PMID: 31553620
The bis-guanidinium ion family of natural products are revered for their utility in the study of ion channel physiology. While many congeners have been isolated with various oxidation and sulfation...