Kai J Neelsen
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Explore the profile of Kai J Neelsen including associated specialties, affiliations and a list of published articles.
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10
Citations
1421
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Recent Articles
1.
Altmeyer M, Neelsen K, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, et al.
Nat Commun
. 2015 Aug;
6:8088.
PMID: 26286827
Intrinsically disordered proteins can phase separate from the soluble intracellular space, and tend to aggregate under pathological conditions. The physiological functions and molecular triggers of liquid demixing by phase separation...
2.
Fugger K, Mistrik M, Neelsen K, Yao Q, Zellweger R, Nedergaard Kousholt A, et al.
Cell Rep
. 2015 Mar;
10(10):1749-1757.
PMID: 25772361
DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It has been suggested that processing of stalled forks might involve fork regression, in which the...
3.
Neelsen K, Lopes M
Nat Rev Mol Cell Biol
. 2015 Feb;
16(4):207-20.
PMID: 25714681
The remodelling of replication forks into four-way junctions following replication perturbation, known as fork reversal, was hypothesized to promote DNA damage tolerance and repair during replication. Albeit conceptually attractive, for...
4.
Kruta M, Seneklova M, Raska J, Salykin A, Zerzankova L, Pesl M, et al.
Stem Cells Dev
. 2014 May;
23(20):2443-54.
PMID: 24836366
The genomic destabilization associated with the adaptation of human embryonic stem cells (hESCs) to culture conditions or the reprogramming of induced pluripotent stem cells (iPSCs) increases the risk of tumorigenesis...
5.
Mejlvang J, Feng Y, Alabert C, Neelsen K, Jasencakova Z, Zhao X, et al.
J Cell Biol
. 2014 Jan;
204(1):29-43.
PMID: 24379417
Correct duplication of DNA sequence and its organization into chromatin is central to genome function and stability. However, it remains unclear how cells coordinate DNA synthesis with provision of new...
6.
Neelsen K, Zanini I, Mijic S, Herrador R, Zellweger R, Ray Chaudhuri A, et al.
Genes Dev
. 2013 Dec;
27(23):2537-42.
PMID: 24298053
Deregulated origin licensing and rereplication promote genome instability and tumorigenesis by largely elusive mechanisms. Investigating the consequences of Early mitotic inhibitor 1 (Emi1) depletion in human cells, previously associated with...
7.
Neelsen K, Ray Chaudhuri A, Follonier C, Herrador R, Lopes M
Methods Mol Biol
. 2013 Oct;
1094:177-208.
PMID: 24162989
The detailed understanding of the DNA replication process requires structural insight. The combination of psoralen cross-linking and electron microscopy has been extensively exploited to reveal the fine architecture of in...
8.
Neelsen K, Zanini I, Herrador R, Lopes M
J Cell Biol
. 2013 Mar;
200(6):699-708.
PMID: 23479741
Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes genome instability and tumor progression, but the underlying molecular mechanisms...
9.
Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen K, Fachinetti D, Bermejo R, et al.
Nat Struct Mol Biol
. 2012 Mar;
19(4):417-23.
PMID: 22388737
Topoisomerase I (Top1) releases torsional stress during DNA replication and transcription and is inhibited by camptothecin and camptothecin-derived cancer chemotherapeutics. Top1 inhibitor cytotoxicity is frequently linked to double-strand break (DSB)...
10.
Toller I, Neelsen K, Steger M, Hartung M, Hottiger M, Stucki M, et al.
Proc Natl Acad Sci U S A
. 2011 Sep;
108(36):14944-9.
PMID: 21896770
The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric...