Raquel Herrador
Overview
Explore the profile of Raquel Herrador including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1252
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0
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Recent Articles
1.
Vujanovic M, Krietsch J, Raso M, Terraneo N, Zellweger R, Schmid J, et al.
Mol Cell
. 2017 Sep;
67(5):882-890.e5.
PMID: 28886337
DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template...
2.
Ahuja A, Jodkowska K, Teloni F, Bizard A, Zellweger R, Herrador R, et al.
Nat Commun
. 2016 Feb;
7:10660.
PMID: 26876348
Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active DNA damage response (DDR), but its molecular determinants have...
3.
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al.
J Cell Biol
. 2015 Mar;
208(5):563-79.
PMID: 25733714
Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of sublethal...
4.
Ray Chaudhuri A, Ahuja A, Herrador R, Lopes M
Mol Cell Biol
. 2014 Dec;
35(5):856-65.
PMID: 25535335
Poly(ADP-ribosyl)ation (PAR) has been implicated in various aspects of the cellular response to DNA damage and genome stability. Although 17 human poly(ADP-ribose) polymerase (PARP) genes have been identified, a single...
5.
Neelsen K, Zanini I, Mijic S, Herrador R, Zellweger R, Ray Chaudhuri A, et al.
Genes Dev
. 2013 Dec;
27(23):2537-42.
PMID: 24298053
Deregulated origin licensing and rereplication promote genome instability and tumorigenesis by largely elusive mechanisms. Investigating the consequences of Early mitotic inhibitor 1 (Emi1) depletion in human cells, previously associated with...
6.
Neelsen K, Ray Chaudhuri A, Follonier C, Herrador R, Lopes M
Methods Mol Biol
. 2013 Oct;
1094:177-208.
PMID: 24162989
The detailed understanding of the DNA replication process requires structural insight. The combination of psoralen cross-linking and electron microscopy has been extensively exploited to reveal the fine architecture of in...
7.
Neelsen K, Zanini I, Herrador R, Lopes M
J Cell Biol
. 2013 Mar;
200(6):699-708.
PMID: 23479741
Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes genome instability and tumor progression, but the underlying molecular mechanisms...
8.
Follonier C, Oehler J, Herrador R, Lopes M
Nat Struct Mol Biol
. 2013 Mar;
20(4):486-94.
PMID: 23454978
Expansion of GAA/TTC repeats is the causative event in Friedreich's ataxia. GAA repeats have been shown to hinder replication in model systems, but the mechanisms of replication interference and expansion...
9.
Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen K, Fachinetti D, Bermejo R, et al.
Nat Struct Mol Biol
. 2012 Mar;
19(4):417-23.
PMID: 22388737
Topoisomerase I (Top1) releases torsional stress during DNA replication and transcription and is inhibited by camptothecin and camptothecin-derived cancer chemotherapeutics. Top1 inhibitor cytotoxicity is frequently linked to double-strand break (DSB)...