Kai H Barck
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Explore the profile of Kai H Barck including associated specialties, affiliations and a list of published articles.
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20
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985
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Recent Articles
1.
Virgincar R, Wong A, Barck K, Webster J, Hung J, Caplazi P, et al.
Am J Physiol Renal Physiol
. 2024 Jun;
327(2):F235-F244.
PMID: 38867676
Chronic kidney disease (CKD) is characterized by inflammation and fibrosis in the kidney. Renal biopsies and estimated glomerular filtration rate (eGFR) remain the standard of care, but these endpoints have...
2.
Ferl G, Barck K, Patil J, Jemaa S, Malamut E, Lima A, et al.
iScience
. 2022 Dec;
25(12):105712.
PMID: 36582483
Here, we have developed an automated image processing algorithm for segmenting lungs and individual lung tumors in micro-computed tomography (micro-CT) scans of mouse models of non-small cell lung cancer and...
3.
Lee S, Meilandt W, Xie L, Gandham V, Ngu H, Barck K, et al.
Neuron
. 2021 Mar;
109(8):1283-1301.e6.
PMID: 33675684
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2...
4.
Balestrini A, Joseph V, Dourado M, Reese R, Shields S, Rouge L, et al.
J Exp Med
. 2021 Feb;
218(4).
PMID: 33620419
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are...
5.
Sengupta-Ghosh A, Dominguez S, Xie L, Barck K, Jiang Z, Earr T, et al.
Neurobiol Dis
. 2019 Sep;
132:104558.
PMID: 31471201
No abstract available.
6.
Wu T, Dejanovic B, Gandham V, Gogineni A, Edmonds R, Schauer S, et al.
Cell Rep
. 2019 Aug;
28(8):2111-2123.e6.
PMID: 31433986
Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely...
7.
Sengupta-Ghosh A, Dominguez S, Xie L, Barck K, Jiang Z, Earr T, et al.
Neurobiol Dis
. 2018 Dec;
124:340-352.
PMID: 30528255
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the...
8.
Senger K, Pham V, Varfolomeev E, Hackney J, Corzo C, Collier J, et al.
Sci Signal
. 2017 Apr;
10(475).
PMID: 28420753
Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK kinases MEK1 and MEK2 (MEK1/2), which, in turn,...
9.
Barck K, Bou-Reslan H, Rastogi U, Sakhuja T, Long J, Molina R, et al.
Transl Oncol
. 2015 May;
8(2):126-35.
PMID: 25926079
Genetically engineered mouse models (GEMMs) of lung cancer closely recapitulate the human disease but suffer from the difficulty of evaluating tumor growth by conventional methods. Herein, a novel automated image...
10.
Johnson L, Huseni M, Smyczek T, Lima A, Yeung S, Cheng J, et al.
J Clin Invest
. 2013 Aug;
123(9):3997-4009.
PMID: 23945239
Many oncology drugs are administered at their maximally tolerated dose without the knowledge of their optimal efficacious dose range. In this study, we describe a multifaceted approach that integrated preclinical...