K W Scotto
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Explore the profile of K W Scotto including associated specialties, affiliations and a list of published articles.
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24
Citations
611
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Recent Articles
1.
Scotto K, Egan D
Cytotechnology
. 2008 Nov;
27(1-3):257-69.
PMID: 19002797
The emergence of resistance in a tumor population is most often associated with a disregulation of gene expression, usually at the level of transcription. A major goal in the field...
2.
Scotto K, Johnson R
Mol Interv
. 2004 Mar;
1(2):117-25.
PMID: 14993331
Two decades ago, the overexpression of P-glycoprotein (Pgp) was first demonstrated to mediate the energy-dependent efflux of a variety of chemotherapeutic agents from tumor cells, resulting in the development of...
3.
Lin Y, Ince T, Scotto K
Biochemistry
. 2001 Oct;
40(43):12959-66.
PMID: 11669633
Previous work from our laboratory has allowed for the subdivision of RNA polymerase II TATA-less promoters into two classes: those that initiate at a single start site (SSS) and those...
4.
Takahashi N, Li W, Banerjee D, Scotto K, Bertino J
Clin Cancer Res
. 2001 Oct;
7(10):3251-7.
PMID: 11595721
Ecteinascidin 743 (ET-743) is a potent antitumor agent from the Caribbean tunicate Ecteinascidin turbinata and is presently in clinical trials for human cancers. To better understand how ET-743 might be...
5.
Johnson R, Ince T, Scotto K
J Biol Chem
. 2001 May;
276(29):27716-20.
PMID: 11350951
The tumor suppressor protein p53 has been well documented as a transcriptional activator involved in the regulation of a number of critical genes involved in the cell cycle, response to...
6.
Jin S, Gorfajn B, Faircloth G, Scotto K
Proc Natl Acad Sci U S A
. 2000 Jun;
97(12):6775-9.
PMID: 10841572
Ecteinascidin 743 (ET-743), a highly promising marine-based antitumor agent presently in phase II clinical trials, has been shown to interfere with the binding of minor-groove-interacting transcription factors, particularly NF-Y, with...
7.
Glick R, Medary I, Aronson D, Scotto K, Swendeman S, La Quaglia M
J Pediatr Surg
. 2000 Mar;
35(3):465-72.
PMID: 10726691
Background/purpose: Neuroblastoma is the most solid common extracranial malignancy in childhood. Despite multimodality treatment, high-risk disease continues to carry a poor prognosis. Glucocorticoids have been shown previously to induce differentiation...
8.
Hu Z, Jin S, Scotto K
J Biol Chem
. 2000 Jan;
275(4):2979-85.
PMID: 10644769
The MDR1 promoter is subject to control by various internal and external stimuli. We have previously shown that the CCAAT box-binding protein, NF-Y, mediates MDR1 activation by the histone deacetylase...
9.
Abolhoda A, Wilson A, Ross H, Danenberg P, Burt M, Scotto K
Clin Cancer Res
. 1999 Dec;
5(11):3352-6.
PMID: 10589744
Overexpression of P-glycoprotein (Pgp), a multidrug transporter encoded by the MDR1 gene, is associated with chemoresistance in some human solid tumor malignancies. To date, analyses of MDR1 levels in solid...
10.
Jin S, Scotto K
Mol Cell Biol
. 1998 Jun;
18(7):4377-84.
PMID: 9632821
Recent studies have shown that the histone-modifying enzymes histone acetyltransferase (HAT) and histone deacetylase (HDAC) are involved in transcriptional activation and repression, respectively. However, little is known about the endogenous...