J L Biedler
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Explore the profile of J L Biedler including associated specialties, affiliations and a list of published articles.
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121
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3335
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Recent Articles
1.
Grandinetti K, Spengler B, Biedler J, Ross R
Oncogene
. 2005 Nov;
25(5):706-12.
PMID: 16278682
In human neuroblastoma tumors, amplification of the N-myc proto-oncogene and loss of all or part of the short arm of chromosome #1 are both associated with a poor prognosis. Accruing...
2.
Nikolopoulos S, Spengler B, Kisselbach K, Evans A, Biedler J, Ross R
Oncogene
. 2000 Feb;
19(3):380-6.
PMID: 10656685
alpha-Actinins are actin-binding proteins important in organization of the cytoskeleton and in cell adhesion. We have cloned and characterized a cDNA from human neuroblastoma cell variants which encodes the second...
3.
Lazarova D, Spengler B, Biedler J, Ross R
Oncogene
. 1999 May;
18(17):2703-10.
PMID: 10348344
N-myc gene copy numbers and transcription rates are similar in N (neuroblastic, tumorigenic) and S (non-neuronal, non-tumorigenic) neuroblastoma cells with chromosomally integrated amplified N-myc genes. However, N cells show significantly...
4.
Roy K, Chiao J, Spengler B, Tolner B, Yang C, Biedler J, et al.
Cancer Genet Cytogenet
. 1998 Aug;
105(1):29-38.
PMID: 9689927
A variant of the L1210 cell (L1210/R83) selected in the presence of the lipophilic antifolate, metoprine, and a concentration of the natural diastereoisomer of 5-formyltetrahydrofolate, lL5CHO-folateH4, suboptimum for growth exhibited...
5.
Ross R, Lazarova D, Manley G, Smitt P, Spengler B, Posner J, et al.
Eur J Cancer
. 1998 Mar;
33(12):2071-4.
PMID: 9516855
HuD is one of a family of neural antigens recognised by the sera of patients with antibody-associated paraneoplastic encephalomyelitis. Localised exclusively to neurons, these proteins are among the earliest markers...
6.
Mickley L, Spengler B, Knutsen T, Biedler J, Fojo T
J Clin Invest
. 1997 Apr;
99(8):1947-57.
PMID: 9109439
Drug resistance, a major obstacle to cancer chemotherapy, can be mediated by MDR-1/P-glycoprotein. Deletion of the first 68 residues of MDR-1 in an adriamycin-selected cell line after a 4;7 translocation,...
7.
Spengler B, Lazarova D, Ross R, Biedler J
Oncol Res
. 1997 Jan;
9(9):467-76.
PMID: 9495452
Neuroblastoma cell lines typically exhibit multiple cell phenotypes, counterparts of those comprising the embryonic neural crest. Expression of the MYCN gene, usually amplified in cell lines, differs markedly among the...
8.
Scala S, Wosikowski K, Giannakakou P, Valle P, Biedler J, Spengler B, et al.
Cancer Res
. 1996 Aug;
56(16):3737-42.
PMID: 8706017
Brain-derived neurotrophic factor (BDNF) and its receptors are necessary for the survival and development of many neuronal cells. Because BDNF and TrkB are expressed in many poor-prognosis neuroblastoma (NB) tumors,...
9.
Levchenko A, Mehta B, Spengler B, Narkar A, Fonti R, Biedler J, et al.
Anal Biochem
. 1996 May;
236(2):338-43.
PMID: 8660514
To date, all reported measurements of multidrug resistance have been semiquantitative. The purpose of the present study is to establish and validate the self-competitive binding assay technique utilizing monoclonal antibody...
10.
Scott A, Rosa E, Mehta B, Divgi C, Finn R, Biedler J, et al.
Nucl Med Biol
. 1995 May;
22(4):497-504.
PMID: 7550027
Multidrug resistance (MDR) in tumors is associated with P-glycoprotein (Pgp) expression. In vivo quantitation of Pgp may allow MDR to be evaluated noninvasively prior to treatment planning. The purpose of...