Erik Chorell
Overview
Explore the profile of Erik Chorell including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
915
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0
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Recent Articles
1.
Nath Das R, Chorell E
Chemistry
. 2025 Feb;
:e202404689.
PMID: 39989204
Non-canonical G-quadruplex (G4) DNA structures play key roles in cellular regulation and are promising targets for cancer therapy. This study reports the design, synthesis, and biophysical evaluation of 15 novel...
2.
Golebiewska-Pikula J, Abrahamsson A, Chorell E
Bioorg Chem
. 2025 Feb;
157:108259.
PMID: 39952062
The continued advancement of oligonucleotide-based strategies in research and therapeutics relies on expanding the repertoire of chemical modifications to overcome persistent challenges, such as improving cellular uptake and delivery. Addressing...
3.
Bag S, Chand K, Burman M, Vertueux S, Chorell E, Bhowmik S
Bioorg Chem
. 2025 Feb;
156:108227.
PMID: 39893993
I-motif (iM) DNA structures are dynamic cytosine-rich secondary structures that are increasingly recognized for their roles in transcriptional regulation, genomic stability, and for their potential as therapeutic targets in cancer....
4.
Berner A, Nath Das R, Bhuma N, Golebiewska J, Abrahamsson A, Andreasson M, et al.
J Am Chem Soc
. 2024 Mar;
146(10):6926-6935.
PMID: 38430200
G-quadruplex (G4) DNA structures are prevalent secondary DNA structures implicated in fundamental cellular functions, such as replication and transcription. Furthermore, G4 structures are directly correlated to human diseases such as...
5.
Andreasson M, Donzel M, Abrahamsson A, Berner A, Doimo M, Quiroga A, et al.
J Med Chem
. 2024 Jan;
67(3):2202-2219.
PMID: 38241609
G-Quadruplex (G4) DNA structures are important regulatory elements in central biological processes. Small molecules that selectively bind and stabilize G4 structures have therapeutic potential, and there are currently >1000 known...
6.
Doimo M, Chaudhari N, Abrahamsson S, LHote V, Nguyen T, Berner A, et al.
Nucleic Acids Res
. 2023 Jun;
51(14):7392-7408.
PMID: 37351621
Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation of mtDNA deletions that associate with genetic inherited disorders and aging. However, the molecular details of how...
7.
Deiana M, Chand K, Chorell E, Sabouri N
J Phys Chem Lett
. 2023 Feb;
14(7):1862-1869.
PMID: 36779779
Molecular self-assembly is a powerful tool for the development of functional nanostructures with adaptive optical properties. However, in aqueous solution, the hydrophobic effects in the monomeric units often afford supramolecular...
8.
Bhuma N, Chand K, Andreasson M, Mason J, Nath Das R, Patel A, et al.
Eur J Med Chem
. 2023 Jan;
248:115103.
PMID: 36645982
G-quadruplex (G4) DNA structures are involved in central biological processes such as DNA replication and transcription. These DNA structures are enriched in promotor regions of oncogenes and are thus promising...
9.
Andreasson M, Bhuma N, Pemberton N, Chorell E
Chemistry
. 2022 Aug;
28(65):e202202020.
PMID: 35997141
This study aims to deepen the knowledge of the current state of rational G4-ligand design through the design and synthesis of a novel set of compounds based on indoles, quinolines,...
10.
Prasad B, Doimo M, Andreasson M, LHote V, Chorell E, Wanrooij S
Chem Sci
. 2022 Mar;
13(8):2347-2354.
PMID: 35310480
G-quadruplex (G4) DNA structures are implicated in central biological processes and are considered promising therapeutic targets because of their links to human diseases such as cancer. However, functional details of...