K J Shaw
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Explore the profile of K J Shaw including associated specialties, affiliations and a list of published articles.
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80
Citations
1966
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Recent Articles
11.
Zhao Z, Arnaiz D, Griedel B, Sakata S, Dallas J, Whitlow M, et al.
Bioorg Med Chem Lett
. 2000 Jun;
10(9):963-6.
PMID: 10853669
Inhibitors based on the benzimidazole scaffold showed subnanomolar potency against Factor Xa with 500-1000-fold selectivity against thrombin and 50-100-fold selectivity against trypsin. The 2-substituent on the benzimidazole ring had a...
12.
Arnaiz D, Zhao Z, Liang A, Trinh L, Witlow M, Koovakkat S, et al.
Bioorg Med Chem Lett
. 2000 Jun;
10(9):957-61.
PMID: 10853668
A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900-...
13.
Whitfield F, Helidoniotis F, Shaw K, Svoronos D
J Agric Food Chem
. 2000 May;
47(6):2367-73.
PMID: 10794638
Forty-nine species (87 samples) of marine macroalgae from eastern Australia were analyzed by GC/MS for the key seafood flavor components 2- and 4-bromophenol, 2,4- and 2,6-dibromophenol, and 2,4, 6-tribromophenol. All...
14.
McNicholas P, Najarian D, Mann P, Hesk D, Hare R, Shaw K, et al.
Antimicrob Agents Chemother
. 2000 Apr;
44(5):1121-6.
PMID: 10770739
Evernimicin (SCH 27899) is a new antibiotic with activity against a wide spectrum of gram-positive bacteria and activity against some gram-negative bacteria. Previous metabolic labeling studies indicated that evernimicin specifically...
15.
Adrian P, Zhao W, Black T, Shaw K, Hare R, Klugman K
Antimicrob Agents Chemother
. 2000 Feb;
44(3):732-8.
PMID: 10681347
A clinical isolate of Streptococcus pneumoniae (SP#5) that showed decreased susceptibility to evernimicin (MIC, 1.5 microgram/ml) was investigated. A 4,255-bp EcoRI fragment cloned from SP#5 was identified by its ability...
16.
Guilford W, Shaw K, Dallas J, Koovakkat S, Lee W, Liang A, et al.
J Med Chem
. 2000 Jan;
42(26):5415-25.
PMID: 10639283
Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in blood coagulation linking the intrinsic and extrinsic pathways to the final common pathway of the coagulation...
17.
Whitfield F, Jensen N, Shaw K
J Dairy Res
. 2000 Jan;
67(4):561-9.
PMID: 11131069
Analysis by gas chromatography-mass spectrometry of pasteurized milk with a fruity (pineapple like) off odour and a sour, rancid and soapy taste indicated the presence of concentrations at microg/ml levels...
18.
Castro M, Fassett M, Reynolds T, Shaw K, Goodwin T
Am J Obstet Gynecol
. 1999 Aug;
181(2):389-95.
PMID: 10454689
Objective: We sought to describe our experience with the clinical diagnosis, management, and course of patients with acute fatty liver of pregnancy. Study Design: Twenty-eight cases of acute fatty liver...
19.
Whitlow M, Arnaiz D, Buckman B, Davey D, Griedel B, Guilford W, et al.
Acta Crystallogr D Biol Crystallogr
. 1999 Jul;
55(Pt 8):1395-404.
PMID: 10417407
Factor Xa is a serine protease which activates thrombin (factor IIa) and plays a key regulatory role in the blood-coagulation cascade. Factor Xa is, therefore, an important target for the...
20.
Viter S, Shaw K, Gennaro M
Res Microbiol
. 1999 Jun;
150(4):287-90.
PMID: 10376491
Histone-like proteins of the HU family are small, sequence-independent DNA binding proteins that facilitate a variety of DNA transactions. Here we report isolation from cell-free extracts of Staphylococcus aureus of...