K H Kaestner
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Explore the profile of K H Kaestner including associated specialties, affiliations and a list of published articles.
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59
Citations
4136
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Recent Articles
11.
Besnard V, Wert S, Kaestner K, Whitsett J
Am J Physiol Lung Cell Mol Physiol
. 2005 Oct;
289(5):L750-9.
PMID: 16214823
Foxa1 is a member of the winged helix family of transcription factors that is expressed in epithelial cells of the conducting airways and in alveolar type II cells of the...
12.
Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut
Perreault N, Katz J, Sackett S, Kaestner K
J Biol Chem
. 2001 Sep;
276(46):43328-33.
PMID: 11555641
Foxl1 is a winged helix transcription factor expressed in the mesenchyme of the gastrointestinal tract. Foxl1 null mice display severe structural defects in the epithelia of the stomach, duodenum, and...
13.
Shen W, Scearce L, Brestelli J, Sund N, Kaestner K
J Biol Chem
. 2001 Sep;
276(46):42812-7.
PMID: 11546810
The winged helix transcription factors, hepatocyte nuclear factors 3alpha, -beta, and -gamma (HNF-3, encoded by the Foxa1, -a2, and -a3 genes, respectively), are expressed early in embryonic endoderm and play...
14.
Waltz S, Eaton L, Hess K, Peace B, Ihlendorf J, Wang M, et al.
J Clin Invest
. 2001 Aug;
108(4):567-76.
PMID: 11518730
Ron receptor activation induces numerous cellular responses in vitro, including proliferation, dissociation, and migration. Ron is thought to be involved in blood cell development in vivo, as well as in...
15.
Silberg D, Kaestner K
Gastroenterology
. 2001 Aug;
121(2):485-7.
PMID: 11487557
No abstract available.
16.
Sund N, Vatamaniuk M, Casey M, Ang S, Magnuson M, Stoffers D, et al.
Genes Dev
. 2001 Jul;
15(13):1706-15.
PMID: 11445544
We have used conditional gene ablation to uncover a dramatic and unpredicted role for the winged-helix transcription factor Foxa2 (formerly HNF-3 beta) in pancreatic beta-cell differentiation and metabolism. Mice that...
17.
Cho H, Mu J, Kim J, Thorvaldsen J, Chu Q, Crenshaw 3rd E, et al.
Science
. 2001 Jun;
292(5522):1728-31.
PMID: 11387480
Glucose homeostasis depends on insulin responsiveness in target tissues, most importantly, muscle and liver. The critical initial steps in insulin action include phosphorylation of scaffolding proteins and activation of phosphatidylinositol...
18.
Mukherjee D, Kaestner K, Kovalovich K, Greenbaum L
Hepatology
. 2001 May;
33(5):1166-72.
PMID: 11343245
Apoptotic cell death in the liver in response to activation of the Fas pathway has been implicated in human disease states as well as liver remodeling and tissue repair. C/EBPbeta,...
19.
Kaestner K
Trends Endocrinol Metab
. 2000 Aug;
11(7):281-5.
PMID: 10920385
The genes encoding hepatocyte nuclear factor 3 (HNF3) proteins play a pivotal role in the regulation of metabolism and in the differentiation of metabolic tissues such as the pancreas and...
20.
Sund N, Ang S, Sackett S, Shen W, Daigle N, Magnuson M, et al.
Mol Cell Biol
. 2000 Jun;
20(14):5175-83.
PMID: 10866673
Liver-specific gene expression is controlled by a heterogeneous group of hepatocyte-enriched transcription factors. One of these, the winged helix transcription factor hepatocyte nuclear factor 3beta (HNF3beta or Foxa2) is essential...