K A Hogquist
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Explore the profile of K A Hogquist including associated specialties, affiliations and a list of published articles.
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33
Citations
2420
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Recent Articles
1.
Daniels M, Devine L, Miller J, MOSER J, Lukacher A, Altman J, et al.
Immunity
. 2002 Jan;
15(6):1051-61.
PMID: 11754824
CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of...
2.
Stefanski H, Mayerova D, Jameson S, Hogquist K
J Immunol
. 2001 May;
166(11):6602-7.
PMID: 11359813
The T cell repertoire is shaped by the processes of positive and negative selection. During development, the TCR binds self peptide-MHC complexes in the thymus, and the kinetics of this...
3.
McGargill M, Derbinski J, Hogquist K
Nat Immunol
. 2001 Mar;
1(4):336-41.
PMID: 11017106
A central tenet of T cell development postulates that if a developing thymocyte encounters self-antigen, it is induced to die via apoptosis, thereby protecting the organism from autoreactive T cells....
4.
Hogquist K
Curr Opin Immunol
. 2001 Mar;
13(2):225-31.
PMID: 11228417
During development, alphabeta T cells undergo positive or negative selection and CD4(+)/CD8(+) lineage commitment-events that have a major impact on the functionality of the T cell repertoire. The precise mechanisms...
5.
6.
Hogquist K
Methods Mol Biol
. 2000 Nov;
156:219-32.
PMID: 11068763
The in vitro methods of FTOC and DP dulling assay have been useful for defining the structural ligand requirements for positive selection of thymocytes. Both techniques, but especially the latter,...
7.
Stefanski H, Jameson S, Hogquist K
J Immunol
. 2000 Mar;
164(7):3519-26.
PMID: 10725706
Recent data suggest that the diversity of self peptides presented in the thymus during development contributes to positive selection of a diverse T cell repertoire. We sought to determine whether...
8.
Daniels M, Schober S, Hogquist K, Jameson S
J Immunol
. 1999 Apr;
162(7):3761-4.
PMID: 10201890
The mechanism by which TCR antagonists interfere with T cell activation is unclear. One popular hypothesis is that incomplete early signaling events induced by these ligands dominantly inhibit the T...
9.
Alam S, Davies G, Lin C, Zal T, Nasholds W, Jameson S, et al.
Immunity
. 1999 Mar;
10(2):227-37.
PMID: 10072075
The kinetics of interaction between TCR and MHC-peptide show a general relationship between affinity and the biological response, but the reported kinetic differences between antigenic and antagonistic peptides are very...
10.
McGargill M, Hogquist K
J Immunol
. 1999 Feb;
162(3):1237-45.
PMID: 9973375
The various stages of T cell development are typically characterized by the expression level of the two coreceptors, CD4 and CD8. During the CD4+CD8+ (double-positive, DP) stage of development, thymocytes...