K A Browne
Overview
Explore the profile of K A Browne including associated specialties, affiliations and a list of published articles.
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25
Citations
508
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Recent Articles
1.
Bull M, Spicer J, Huttunen K, Denny W, Ciccone A, Browne K, et al.
Eur J Drug Metab Pharmacokinet
. 2014 Aug;
40(4):417-25.
PMID: 25155444
The cytolytic protein perforin is a key component of the immune response and is implicated in a number of human pathologies and therapy-induced conditions. A novel series of small molecule...
2.
Smyth M, Kelly J, Sutton V, Davis J, Browne K, Sayers T, et al.
J Leukoc Biol
. 2001 Jul;
70(1):18-29.
PMID: 11435481
Cytotoxic lymphocytes largely comprise CD8(+) cytotoxic T cells and natural killer cells and form the major defense of higher organisms against virus-infected and transformed cells. A key function of cytotoxic...
3.
4.
Sutton V, Davis J, Cancilla M, Johnstone R, Ruefli A, Sedelies K, et al.
J Exp Med
. 2000 Nov;
192(10):1403-14.
PMID: 11085743
The essential upstream steps in granzyme B-mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the mitochondrial apoptotic pathway through direct cleavage of Bid; however, cleavage of procaspases...
5.
Browne K, Johnstone R, Jans D, Trapani J
J Biol Chem
. 2000 Oct;
275(50):39262-6.
PMID: 11050075
We used yeast two-hybrid screening to identify the cytoskeletal protein filamin as a ligand for the proapoptotic protease granzyme B, produced by cytotoxic T lymphocytes. Filamin was directly cleaved by...
6.
Browne K, Blink E, Sutton V, Froelich C, Jans D, Trapani J
Mol Cell Biol
. 1999 Nov;
19(12):8604-15.
PMID: 10567584
Granule-mediated cell killing by cytotoxic lymphocytes requires the combined actions of a membranolytic protein, perforin, and granule-associated granzymes, but the mechanism by which they jointly kill cells is poorly understood....
7.
Edwards K, Davis J, Browne K, Sutton V, Trapani J
Immunol Cell Biol
. 1999 Apr;
77(1):76-89.
PMID: 10101689
Cytotoxic T cells and natural killer cells together constitute a major defence against virus infection, through their ability to induce apoptotic death in infected cells. These cytolytic lymphocytes kill their...
8.
Bondeson J, Browne K, Brennan F, Foxwell B, Feldmann M
J Immunol
. 1999 Mar;
162(5):2939-45.
PMID: 10072544
Macrophages are the major cytokine producers in chronic inflammatory diseases, but the biochemical pathways regulating cytokine production are poorly understood. This is because genetic tools to dissect signaling pathways cannot...
9.
Trapani J, Jans D, Jans P, Smyth M, Browne K, Sutton V
J Biol Chem
. 1998 Oct;
273(43):27934-8.
PMID: 9774406
The secretory lysosomes of cytolytic lymphocytes house the principal apoptotic molecules for eliminating virus-infected cells: a membranolytic agent, perforin, and the serine protease, granzyme B. Perforin allows granzyme B access...
10.
Browne K, Tamburri M, Zimmer-Faust R
J Exp Biol
. 1998 Mar;
201(Pt 2):245-58.
PMID: 9405312
Quantitative structure-activity relationships (QSARs) between the physicochemical properties of environmental signal molecules and animal behaviour have been determined. Past work has shown that oyster and barnacle larval settlement and mud...