Justin C St John
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Explore the profile of Justin C St John including associated specialties, affiliations and a list of published articles.
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76
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1618
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Recent Articles
1.
Andreas E, Penn A, Okada T, St John J
Biomolecules
. 2024 Nov;
14(11).
PMID: 39595653
Mitochondrial DNA (mtDNA) supplementation can rescue poor oocyte quality and overcome embryonic arrest. Here, we investigated a series of sexually mature pigs generated through autologous and heterologous mtDNA supplementation. Brain,...
2.
Okada T, Penn A, St John J
Int J Mol Sci
. 2023 Apr;
24(8).
PMID: 37108708
Oocytes can be supplemented with extra copies of mitochondrial DNA (mtDNA) to enhance developmental outcome. Pigs generated through supplementation with mtDNA derived from either sister (autologous) or third-party (heterologous) oocytes...
3.
Okada T, McIlfatrick S, St John J
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835193
Mitochondrial DNA (mtDNA) deficiency correlates with poor oocyte quality and fertilisation failure. However, the supplementation of mtDNA deficient oocytes with extra copies of mtDNA improves fertilisation rates and embryo development....
4.
McIlfatrick S, OLeary S, Okada T, Penn A, Nguyen V, McKenny L, et al.
iScience
. 2023 Jan;
26(2):105956.
PMID: 36711242
Introducing extra mitochondrial DNA (mtDNA) into oocytes at fertilization can rescue poor quality oocytes. However, supplementation alters DNA methylation and gene expression profiles of preimplantation embryos. To determine if these ...
5.
St John J, Okada T, Andreas E, Penn A
Mol Reprod Dev
. 2022 Aug;
90(7):621-633.
PMID: 35986715
The mitochondrial genome resides in the mitochondria present in nearly all cell types. The porcine (Sus scrofa) mitochondrial genome is circa 16.7 kb in size and exists in the multimeric...
6.
Okada T, McIlfatrick S, Hin N, Aryamanesh N, Breen J, St John J
Epigenetics Chromatin
. 2022 Apr;
15(1):12.
PMID: 35428319
Background: Mitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA through mitochondrial supplementation of mtDNA-deficient Sus scrofa oocytes...
7.
Azumah R, Hummitzsch K, Hartanti M, St John J, Anderson R, Rodgers R
Front Genet
. 2022 Feb;
12:762177.
PMID: 35197999
Polycystic Ovary Syndrome (PCOS) is a multifactorial syndrome with reproductive, endocrine, and metabolic symptoms, affecting about 10% women of reproductive age. Pathogenesis of the syndrome is poorly understood with genetic...
8.
Okada T, Sun X, McIlfatrick S, St John J
NAR Genom Bioinform
. 2022 Jan;
4(1):lqab119.
PMID: 35047811
Mitochondrial DNA (mtDNA) methylation in vertebrates has been hotly debated for over 40 years. Most contrasting results have been reported following bisulfite sequencing (BS-seq) analyses. We addressed whether BS-seq experimental...
9.
St John J
Annu Rev Anim Biosci
. 2021 Feb;
9:203-224.
PMID: 33592161
Our understanding of the interactions between the nuclear and mitochondrial genomes is becoming increasingly important as they are extensively involved in establishing early development and developmental progression. Evidence from various...
10.
Kapetanovic R, Afroz S, Ramnath D, Lawrence G, Okada T, Curson J, et al.
Immunol Cell Biol
. 2020 Jul;
98(7):528-539.
PMID: 32686869
Mitochondria have a multitude of functions, including energy generation and cell signaling. Recent evidence suggests that mitochondrial dynamics (i.e. the balance between mitochondrial fission and fusion) also regulate immune functions....