Ian A Trounce
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Explore the profile of Ian A Trounce including associated specialties, affiliations and a list of published articles.
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62
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2240
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Recent Articles
1.
Chrysostomou V, Ellis S, Fry L, Hatch R, Fahy E, Bell K, et al.
Aging Cell
. 2025 Feb;
:e70005.
PMID: 40016944
Age and elevated intraocular pressure (IOP) are the two major risk factors for developing glaucoma, a leading cause of blindness worldwide that is characterized by the loss of retinal ganglion...
2.
Januszewski A, Blake R, Zhang M, Ma B, Anand S, Pinkert C, et al.
Antioxidants (Basel)
. 2024 Feb;
13(2).
PMID: 38397785
Associations between chronic diabetes complications and mitochondrial dysfunction represent a subject of major importance, given the diabetes pandemic and high personal and socioeconomic costs of diabetes and its complications. Modelling...
3.
Canovai A, Tribble J, Joe M, Westerlund D, Amato R, Trounce I, et al.
Acta Neuropathol Commun
. 2023 Sep;
11(1):146.
PMID: 37684640
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient...
4.
Anand S, Trounce I, Gangoda L
IUBMB Life
. 2022 Oct;
74(12):1264-1272.
PMID: 36308309
Extracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogenesis of certain diseases such as cancer is well...
5.
Singh L, Ennis B, Loneragan B, Tsao N, Lopez Sanchez M, Li J, et al.
PLoS Comput Biol
. 2021 Nov;
17(11):e1009594.
PMID: 34762648
The growing number of next-generation sequencing (NGS) data presents a unique opportunity to study the combined impact of mitochondrial and nuclear-encoded genetic variation in complex disease. Mitochondrial DNA variants and...
6.
Lopez Sanchez M, Ziemann M, Bachem A, Makam R, Crowston J, Pinkert C, et al.
PLoS One
. 2020 Oct;
15(10):e0239804.
PMID: 33031404
Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expression of the nuclear and mitochondrial genomes. This represents a unique challenge that highlights...
7.
Hui F, Tang J, Williams P, McGuinness M, Hadoux X, Casson R, et al.
Clin Exp Ophthalmol
. 2020 Jul;
48(7):903-914.
PMID: 32721104
Importance: Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nicotinamide, a precursor of NAD , is low in serum of glaucoma patients and...
8.
Lopez Sanchez M, Van Bergen N, Kearns L, Ziemann M, Liang H, Hewitt A, et al.
Mitochondrion
. 2020 Jul;
54:113-121.
PMID: 32687992
Leber hereditary optic neuropathy (LHON) is one of the most common primary mitochondrial diseases. It is caused by point mutations in mitochondrial DNA (mtDNA) genes and in some cases, it...
9.
Burgin H, Lopez Sanchez M, Smith C, Trounce I, McKenzie M
Int J Mol Sci
. 2020 Apr;
21(6).
PMID: 32244971
The lack of effective treatments for mitochondrial disease has seen the development of new approaches, including those that aim to stimulate mitochondrial biogenesis to boost ATP generation above a critical...
10.
Cimdins K, Waugh H, Chrysostomou V, Lopez Sanchez M, Johanssen V, Cook M, et al.
Mol Neurobiol
. 2019 Aug;
56(10):7249.
PMID: 31410736
The original version of this article unfortunately contained a mistake in the author name. The family name of Dr. Vanessa A. Johannsen should be written as "Johanssen."