Justin C St John
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Explore the profile of Justin C St John including associated specialties, affiliations and a list of published articles.
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76
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1618
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Recent Articles
11.
St John J
Cells
. 2019 Oct;
8(11).
PMID: 31652817
It is becoming increasingly apparent that cells require cooperation between the nuclear and mitochondrial genomes to promote effective function. However, it was long thought that the mitochondrial genome was under...
12.
St John J
Cells
. 2019 Aug;
8(8).
PMID: 31398797
Mitochondria and mitochondrial DNA have important roles to play in development. In primordial germ cells, they progress from small numbers to populate the maturing oocyte with high numbers to support...
13.
St John J, Makanji Y, Johnson J, Tsai T, Lagondar S, Rodda F, et al.
Sci Rep
. 2019 May;
9(1):6694.
PMID: 31040316
Many women suffer from either failed fertilisation or their embryos arrest early during development. Autologous mitochondrial supplementation has been proposed as an assisted reproductive technology to overcome these problems. However,...
14.
Srirattana K, St John J
Adv Anat Embryol Cell Biol
. 2019 Jan;
231:75-103.
PMID: 30617719
Mitochondrial DNA (mtDNA) encodes proteins for the electron transport chain which produces the vast majority of cellular energy. MtDNA has its own replication and transcription machinery that relies on nuclear-encoded...
15.
Sun X, Vaghjiani V, Jayasekara W, Cain J, St John J
Clin Epigenetics
. 2018 Dec;
10(1):157.
PMID: 30558637
Background: Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differentiation....
16.
Sun X, St John J
Epigenetics Chromatin
. 2018 Sep;
11(1):53.
PMID: 30208958
Background: There are multiple copies of mitochondrial DNA (mtDNA) present in each cell type, and they are strictly regulated in a cell-specific manner by a group of nuclear-encoded mtDNA-specific replication...
17.
St John J, Tsai T
BMC Genet
. 2018 Jul;
19(1):41.
PMID: 29980191
Background: The mitochondrial genome (mtDNA) is an emerging determiner of phenotypic traits and disease. mtDNA is inherited in a strict maternal fashion from the population of mitochondria present in the...
18.
Srirattana K, St John J
Sci Rep
. 2018 May;
8(1):7246.
PMID: 29740154
We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) modulates the nuclear genome. To eliminate any confounding...
19.
Sun X, Johnson J, St John J
Nucleic Acids Res
. 2018 May;
46(12):5977-5995.
PMID: 29722878
Replication of mitochondrial DNA is strictly regulated during differentiation and development allowing each cell type to acquire its required mtDNA copy number to meet its specific needs for energy. Undifferentiated...
20.
Tsai T, St John J
Mol Reprod Dev
. 2018 Apr;
85(6):490-504.
PMID: 29663563
Mitochondrial DNA (mtDNA) deficient metaphase II porcine oocytes are less likely to fertilize and more likely to arrest during preimplantation development. However, they can be supplemented with autologous populations of...