Jurg Tschopp
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Explore the profile of Jurg Tschopp including associated specialties, affiliations and a list of published articles.
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Articles
149
Citations
37197
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Recent Articles
1.
Chen K, Gross C, Vasquez Sotomayor F, Stacey K, Tschopp J, Sweet M, et al.
Cell Rep
. 2014 Jul;
8(2):570-82.
PMID: 25043180
The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other...
2.
Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, et al.
J Exp Med
. 2013 Sep;
210(11):2465-76.
PMID: 24062413
NOD2 functions as an intracellular sensor for microbial pathogen and plays an important role in epithelial defense. The loss-of-function mutation of NOD2 is strongly associated with human Crohn's disease (CD)....
3.
Allam R, Darisipudi M, Tschopp J, Anders H
Eur J Immunol
. 2013 Aug;
43(12):3336-42.
PMID: 23964013
Sterile cell death mediated inflammation is linked to several pathological disorders and involves danger recognition of intracellular molecules released by necrotic cells that activate different groups of innate pattern recognition...
4.
Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, et al.
Immunity
. 2013 Jul;
38(6):1154-63.
PMID: 23809162
Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with...
5.
Drexler S, Bonsignore L, Masin M, Tardivel A, Jackstadt R, Hermeking H, et al.
Proc Natl Acad Sci U S A
. 2012 Oct;
109(45):18384-9.
PMID: 23090995
A chronic inflammatory microenvironment favors tumor progression through molecular mechanisms that are still incompletely defined. In inflammation-induced skin cancers, IL-1 receptor- or caspase-1-deficient mice, or mice specifically deficient for the...
6.
NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma
Chow M, Tschopp J, Moller A, Smyth M
Immunol Cell Biol
. 2012 Sep;
90(10):983-6.
PMID: 23010873
Asbestos exposure can result in serious and frequently lethal diseases, including malignant mesothelioma. The host sensor for asbestos-induced inflammation is the NLRP3 inflammasome and it is widely assumed that this...
7.
Chow M, Sceneay J, Paget C, Wong C, Duret H, Tschopp J, et al.
Cancer Res
. 2012 Sep;
72(22):5721-32.
PMID: 22986739
The NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response upon infectious insults or tissue injury and damage. However, the role of the NLRP3...
8.
Schweneker K, Gorka O, Schweneker M, Poeck H, Tschopp J, Peschel C, et al.
Immunobiology
. 2012 Aug;
218(4):664-73.
PMID: 22921586
The success of a vaccine consists in the induction of an innate immune response and subsequent activation of the adaptive immune system. Because antigens are usually not immunogenic, the addition...
9.
Ando K, Kernan J, Liu P, Sanda T, Logette E, Tschopp J, et al.
Mol Cell
. 2012 Aug;
47(5):681-93.
PMID: 22854598
Biochemical evidence implicates the death-domain (DD) protein PIDD as a molecular switch capable of signaling cell survival or death in response to genotoxic stress. PIDD activity is determined by binding-partner...
10.
Erener S, Petrilli V, Kassner I, Minotti R, Castillo R, Santoro R, et al.
Mol Cell
. 2012 Apr;
46(2):200-11.
PMID: 22464733
Caspase 1 is part of the inflammasome, which is assembled upon pathogen recognition, while caspases 3 and/or 7 are mediators of apoptotic and nonapoptotic functions. PARP1 cleavage is a hallmark...