Jurg Tschopp
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Explore the profile of Jurg Tschopp including associated specialties, affiliations and a list of published articles.
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149
Citations
37197
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Recent Articles
11.
Gross O, Yazdi A, Thomas C, Masin M, Heinz L, Guarda G, et al.
Immunity
. 2012 Mar;
36(3):388-400.
PMID: 22444631
Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β), inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1β, little is known about...
12.
Staehli F, Ludigs K, Heinz L, Seguin-Estevez Q, Ferrero I, Braun M, et al.
J Immunol
. 2012 Mar;
188(8):3820-8.
PMID: 22412192
Nucleotide-binding oligomerization domain-like receptors (NLRs) are intracellular proteins involved in innate-driven inflammatory responses. The function of the family member NLR caspase recruitment domain containing protein 5 (NLRC5) remains a matter...
13.
Vince J, Wong W, Gentle I, Lawlor K, Allam R, OReilly L, et al.
Immunity
. 2012 Feb;
36(2):215-27.
PMID: 22365665
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we...
14.
Kupz A, Guarda G, Gebhardt T, Sander L, Short K, Diavatopoulos D, et al.
Nat Immunol
. 2012 Jan;
13(2):162-9.
PMID: 22231517
Memory T cells exert antigen-independent effector functions, but how these responses are regulated is unclear. We discovered an in vivo link between flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells...
15.
Dorhoi A, Nouailles G, Jorg S, Hagens K, Heinemann E, Pradl L, et al.
Eur J Immunol
. 2011 Nov;
42(2):374-84.
PMID: 22101787
As a hallmark of tuberculosis (TB), Mycobacterium tuberculosis (MTB) induces granulomatous lung lesions and systemic inflammatory responses during active disease. Molecular regulation of inflammation is associated with inflammasome assembly. We...
16.
Gross O, Thomas C, Guarda G, Tschopp J
Immunol Rev
. 2011 Sep;
243(1):136-51.
PMID: 21884173
An inflammasome is a multiprotein complex that serves as a platform for caspase-1 activation and caspase-1-dependent proteolytic maturation and secretion of interleukin-1β (IL-1β). Though a number of inflammasomes have been...
17.
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, et al.
J Immunol
. 2011 Jun;
187(1):434-40.
PMID: 21646297
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the pathogenicity and invasiveness. We tested the hypotheses...
18.
Tschopp J
Eur J Immunol
. 2011 Apr;
41(5):1196-202.
PMID: 21469137
NLRP3 inflammasome-dependent inflammatory responses are triggered by a variety of signals of host danger, including infection, tissue damage and metabolic dysregulation. How these diverse activators cause inflammasome activation is poorly...
19.
Mankan A, Canli O, Schwitalla S, Ziegler P, Tschopp J, Korn T, et al.
Proc Natl Acad Sci U S A
. 2011 Apr;
108(16):6567-72.
PMID: 21464320
Loss of IκB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes neutrophilia in Ikkβ-deficient mice. TNF-α-dependent...
20.
Flach T, Ng G, Hari A, Desrosiers M, Zhang P, Ward S, et al.
Nat Med
. 2011 Mar;
17(4):479-87.
PMID: 21399646
As an approved vaccine adjuvant for use in humans, alum has vast health implications, but, as it is a crystal, questions remain regarding its mechanism. Furthermore, little is known about...