Junyan Lu
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Explore the profile of Junyan Lu including associated specialties, affiliations and a list of published articles.
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80
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1617
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Recent Articles
1.
Zhu D, Hu J, Tan R, Lin X, Wang R, Lu J, et al.
Nat Prod Bioprospect
. 2025 Mar;
15(1):16.
PMID: 40042546
Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecular targets and insufficient research on mechanisms of action. In this study,...
2.
Chong S, Lu J, Valentin R, Lehmberg T, Eu J, Wang J, et al.
Mol Cancer
. 2025 Mar;
24(1):62.
PMID: 40025512
Background: Established genetic biomarkers in chronic lymphocytic leukemia (CLL) have been useful in predicting response to chemoimmunotherapy but are less predictive of response to targeted therapies. With several such targeted...
3.
Wan J, Hu Z, Zhu H, Li J, Zheng Z, Deng Z, et al.
Pharmacol Res
. 2025 Feb;
213:107648.
PMID: 39923924
Sphingolipids are critical components of cellular membranes that play a pivotal role in modulating ion channel function by forming lipid rafts that stabilize and localize these channels. These lipids regulate...
4.
Pohly M, Putzker K, Scheinost S, Ben Taarit L, Walther T, Kummer S, et al.
Blood
. 2025 Jan;
PMID: 39869826
T-cell prolymphocytic leukemia (T-PLL) is an aggressive lymphoid malignancy with limited treatment options. To discover new treatment targets for T-PLL, we performed high-throughput drug sensitivity screening on 30 primary patient...
5.
Chapaprieta V, Maiques-Diaz A, Nadeu F, Clot G, Massoni-Badosa R, Mozas P, et al.
Blood
. 2025 Jan;
PMID: 39841466
Previous studies have reported that chronic lymphocytic leukemia (CLL) shows a de novo chromatin activation pattern as compared to normal B cells. Here, we explored whether the level of chromatin...
6.
Wang S, Lu J
Comput Biol Chem
. 2025 Jan;
115:108339.
PMID: 39793513
Background: Feature rankings are crucial in bioinformatics but can be distorted by influential points (IPs), which are often overlooked. This study aims to investigate the impact of IPs on feature...
7.
Kobbe G, Bruggemann M, Baermann B, Wiegand L, Trautmann H, Yousefian S, et al.
N Engl J Med
. 2024 Nov;
391(13):1217-1226.
PMID: 39589371
The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary...
8.
Wang S, Wang S, Pan W, Yi Y, Lu J
PLoS Comput Biol
. 2024 Sep;
20(9):e1012444.
PMID: 39255326
Multiple myeloma (MM) is a hematological disease exhibiting aberrant clonal expansion of cancerous plasma cells in the bone marrow. The effects of treatments for MM vary between patients, highlighting the...
9.
Xu H, Lu J, Li Z, Chen R
J Vis Exp
. 2024 Sep;
(210).
PMID: 39248491
When monitoring minimal residual disease (MRD) after tumor treatment, there are higher requirements of the lower limit of detection than when detecting for drug resistance mutations and circulating tumor cell...
10.
Fang Z, Raza U, Song J, Lu J, Yao S, Liu X, et al.
ESC Heart Fail
. 2024 Jul;
PMID: 39034866
Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left...