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Jun O Liu

Explore the profile of Jun O Liu including associated specialties, affiliations and a list of published articles. Areas
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Articles 183
Citations 7772
Followers 0
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Recent Articles
1.
Peng H, Guo Z, Wang W, Yin D, Zou S, Asbell T, et al.
bioRxiv . 2025 Mar; PMID: 40060691
The 19S regulatory particle (RP) associates with the 20S core particle (CP) to form the 26S proteasome, an evolutionarily conserved holoenzyme that plays key roles in both physiological and pathological...
2.
Marrone M, Reuss J, Crawford A, Neelon B, Liu J, Brahmer J, et al.
Clin Lung Cancer . 2025 Jan; PMID: 39818516
Objective: To determine the association between concurrent statin use with immune checkpoint inhibitors (ICIs) and lung cancer-specific and overall mortality in patients with nonsmall cell lung cancer (NSCLC). Materials And...
3.
Schneider-Poetsch T, Dang Y, Iwasaki W, Arata M, Shichino Y, Al Mourabit A, et al.
Nat Commun . 2025 Jan; 16(1):223. PMID: 39794322
Natural products have a long history of providing probes into protein biosynthesis, with many of these compounds serving as therapeutics. The marine natural product girolline has been described as an...
4.
Kelpsch D, Zhang L, Thierer J, Koren K, Kumar U, Lin Y, et al.
bioRxiv . 2024 Nov; PMID: 39605440
Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which are responsible for transporting...
5.
Matsushita Y, Norris A, Zhong Y, Begum A, Liang H, Debeljak M, et al.
J Chemother . 2024 Sep; :1-15. PMID: 39282901
Better models are needed to identify active drugs to treat pancreatic adenocarcinoma (PAC) patients. We used 3D hanging drop cultures to produce spheroids from five PAC cell lines and tested...
6.
Li Q, Liu Y, Wu J, Zhu Z, Fan J, Zhai L, et al.
Leukemia . 2024 Jun; 38(8):1751-1763. PMID: 38909089
Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed in various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction involves the dynamic regulation of the suppressor...
7.
Qiu H, Qian S, Head S, Sanchez P, Liu J, Jin Z
Bioorg Med Chem Lett . 2024 Apr; 105:129741. PMID: 38599296
ZJ-101, a structurally simplified analog of marine natural product superstolide A, was previously designed and synthesized in our laboratory. In the present study four new analogs of ZJ-101 were designed...
8.
Fang H, Wang X, Damarla M, Sun R, He Q, Li R, et al.
Mediators Inflamm . 2023 Oct; 2023:5133505. PMID: 37840694
Sepsis is one of the most severe complications and causes of mortality in the clinic. It remains a great challenge with no effective treatment for clinicians worldwide. Inhibiting the release...
9.
Liu J
Science . 2023 Aug; 381(6659):729-730. PMID: 37590349
Molecular glues suppress the active form of the oncogenic protein KRAS.
10.
Zhu P, Li S, Ding J, Fei Z, Sun S, Zheng Z, et al.
J Pharm Anal . 2023 Jul; 13(6):616-624. PMID: 37440907
Glioblastoma (GBM) is a lethal cancer with limited therapeutic options. Dendritic cell (DC)-based cancer vaccines provide a promising approach for GBM treatment. Clinical studies suggest that other immunotherapeutic agents may...