Julio C Morales
Overview
Explore the profile of Julio C Morales including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
1078
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Dang T, Lerner M, Saunders D, Smith N, Gulej R, Zalles M, et al.
Cells
. 2022 May;
11(9).
PMID: 35563787
One of the major obstacles in treating brain cancers, particularly glioblastoma multiforme, is the occurrence of secondary tumor lesions that arise in areas of the brain and are inoperable while...
2.
Dang T, Morales J
Cancers (Basel)
. 2021 Jul;
13(13).
PMID: 34206916
Centromere Protein I (CENP-I) is a member of the CENP-H/I/K complex. CENP-H/I/K is a major component of the inner kinetochore and aids in ensuring proper chromosomal segregation during mitosis. In...
3.
Dang T, McIntosh A, Morales J, Pearson G
Int J Mol Sci
. 2020 Dec;
22(1).
PMID: 33374314
Using a data driven analysis of a high-content screen, we have uncovered new regulators of epithelial-to-mesenchymal transition (EMT) induced cell migration. Our results suggest that increased expression of miR614 can...
4.
Patidar P, Viera T, Morales J, Singh N, Motea E, Khandelwal M, et al.
Sci Rep
. 2020 Aug;
10(1):14253.
PMID: 32859985
Persistent R-loops (RNA-DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5'-3'-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination....
5.
Dang T, Morales J
Cancers (Basel)
. 2020 Jul;
12(7).
PMID: 32645903
It was recently shown that the 5' to 3' exoribonuclease XRN2 is involved in the DNA damage response. Importantly, loss of XRN2 abrogates DNA double stranded break repair via the...
6.
Dang T, Morales J
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32549188
Cellular survival is dependent on the efficient replication and transmission of genomic information. DNA damage can be introduced into the genome by several different methods, one being the act of...
7.
Motea E, Fattah F, Xiao L, Girard L, Rommel A, Morales J, et al.
Clin Cancer Res
. 2018 Aug;
24(24):6459-6470.
PMID: 30108102
Purpose: Identification of novel strategies to expand the use of PARP inhibitors beyond BRCA deficiency is of great interest in personalized medicine. Here, we investigated the unannotated role of Kub5-Hera...
8.
Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al.
PLoS Genet
. 2016 Jul;
12(7):e1006107.
PMID: 27437695
XRN2 is a 5'-3' exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop structures and prevention of...
9.
Tang K, Constanzo J, Venkateswaran N, Melegari M, Ilcheva M, Morales J, et al.
Clin Cancer Res
. 2016 May;
22(23):5851-5863.
PMID: 27220963
Purpose: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide due to the limited availability of effective therapeutic options. For instance, there are no effective strategies...
10.
Patidar P, Motea E, Fattah F, Zhou Y, Morales J, Xie Y, et al.
Nucleic Acids Res
. 2016 Jan;
44(4):1718-31.
PMID: 26819409
Ku70-binding protein 5 (Kub5)-Hera (K-H)/RPRD1B maintains genetic integrity by concomitantly minimizing persistent R-loops and promoting repair of DNA double strand breaks (DSBs). We used tandem affinity purification-mass spectrometry, co-immunoprecipitation and...