Julien Bacal
Overview
Explore the profile of Julien Bacal including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
589
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sheedy C, Chowdhury S, Ali B, Miyamoto J, Pang E, Bacal J, et al.
bioRxiv
. 2024 Dec;
PMID: 39713301
The PEX1/PEX6 AAA-ATPase is required for the biogenesis and maintenance of peroxisomes. Mutations in and disrupt peroxisomal matrix protein import and are the leading cause of Peroxisome Biogenesis Disorders (PBDs)....
2.
Vu J, Tavasoli K, Sheedy C, Chowdhury S, Mandjikian L, Bacal J, et al.
J Cell Biol
. 2024 Jul;
223(10).
PMID: 38967608
Peroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans, peroxisomes are required for normal development, yet the genes regulating peroxisome function remain unclear. We performed a genome-wide CRISPRi screen to...
3.
Chowdhury S, Solley S, Polishchuk E, Bacal J, Conrad J, Gardner B, et al.
Mol Biol Cell
. 2024 Apr;
35(6):br12.
PMID: 38656789
The endoplasmic reticulum (ER) is a single-copy organelle that cannot be generated de novo, suggesting coordination between the mechanisms overseeing ER integrity and those controlling the cell cycle to maintain...
4.
Vu J, Tavasoli K, Mandjikian L, Sheedy C, Bacal J, Morrissey M, et al.
bioRxiv
. 2024 Feb;
PMID: 38352406
Peroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans, peroxisomes are required for normal development, yet the genes regulating peroxisome function remain unclear. We performed a genome-wide CRISPRi screen to...
5.
Ghasemi H, Bacal J, Yoon A, Tavasoli K, Cruz C, Vu J, et al.
Nat Biotechnol
. 2023 Feb;
41(10):1398-1404.
PMID: 36849829
We describe a strategy to boost the efficiency of gene editing via homology-directed repair (HDR) by covalently modifying the template DNA with interstrand crosslinks. Crosslinked templates (xHDRTs) increase Cas9-mediated editing...
6.
Mehibel M, Xu Y, Li C, Moon E, Thakkar K, Diep A, et al.
J Clin Invest
. 2021 Jun;
131(11).
PMID: 34060485
Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through...
7.
Bai G, Kermi C, Stoy H, Schiltz C, Bacal J, Zaino A, et al.
Mol Cell
. 2020 May;
78(6):1237-1251.e7.
PMID: 32442397
DNA replication stress can stall replication forks, leading to genome instability. DNA damage tolerance pathways assist fork progression, promoting replication fork reversal, translesion DNA synthesis (TLS), and repriming. In the...
8.
Bacal J, Moriel-Carretero M, Pardo B, Barthe A, Sharma S, Chabes A, et al.
EMBO J
. 2018 Aug;
37(21).
PMID: 30158111
The S-phase checkpoint maintains the integrity of the genome in response to DNA replication stress. In budding yeast, this pathway is initiated by Mec1 and is amplified through the activation...
9.
Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty B, Bacal J, et al.
Proc Natl Acad Sci U S A
. 2016 Jun;
113(26):E3639-48.
PMID: 27298353
Several important physiological transactions, including control of replicative life span (RLS), prevention of collision between replication and transcription, and cellular differentiation, require programmed replication fork arrest (PFA). However, a general...
10.
Slaats G, Saldivar J, Bacal J, Zeman M, Kile A, Hynes A, et al.
J Clin Invest
. 2015 Aug;
125(9):3657-66.
PMID: 26301811
Juvenile ciliopathy syndromes that are associated with renal cysts and premature renal failure are commonly the result of mutations in the gene encoding centrosomal protein CEP290. In addition to centrosomes...