Brooke M Gardner
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Explore the profile of Brooke M Gardner including associated specialties, affiliations and a list of published articles.
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17
Citations
897
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Recent Articles
1.
Miller W, Mishra A, Sheedy C, Bond A, Gardner B, Montell D, et al.
bioRxiv
. 2025 Feb;
PMID: 39990418
CD47 is expressed by viable cells to protect against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 and...
2.
Sheedy C, Chowdhury S, Ali B, Miyamoto J, Pang E, Bacal J, et al.
bioRxiv
. 2024 Dec;
PMID: 39713301
The PEX1/PEX6 AAA-ATPase is required for the biogenesis and maintenance of peroxisomes. Mutations in and disrupt peroxisomal matrix protein import and are the leading cause of Peroxisome Biogenesis Disorders (PBDs)....
3.
Najarro G, Brackett K, Woosley H, Dorman L, Turon-Lagot V, Khadka S, et al.
PLoS Pathog
. 2024 Oct;
20(10):e1012660.
PMID: 39471213
The Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP's function is often dysregulated in cancer and...
4.
Vu J, Tavasoli K, Sheedy C, Chowdhury S, Mandjikian L, Bacal J, et al.
J Cell Biol
. 2024 Jul;
223(10).
PMID: 38967608
Peroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans, peroxisomes are required for normal development, yet the genes regulating peroxisome function remain unclear. We performed a genome-wide CRISPRi screen to...
5.
Chowdhury S, Solley S, Polishchuk E, Bacal J, Conrad J, Gardner B, et al.
Mol Biol Cell
. 2024 Apr;
35(6):br12.
PMID: 38656789
The endoplasmic reticulum (ER) is a single-copy organelle that cannot be generated de novo, suggesting coordination between the mechanisms overseeing ER integrity and those controlling the cell cycle to maintain...
6.
Miller A, Chowdhury S, Hanson H, Linderman S, Ghasemi H, Miller W, et al.
J Biol Eng
. 2024 Apr;
18(1):30.
PMID: 38649904
Aquaporin-1 (Aqp1), a water channel, has garnered significant interest for cell-based medicine and in vivo synthetic biology due to its ability to be genetically encoded to produce magnetic resonance signals...
7.
Vu J, Tavasoli K, Mandjikian L, Sheedy C, Bacal J, Morrissey M, et al.
bioRxiv
. 2024 Feb;
PMID: 38352406
Peroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans, peroxisomes are required for normal development, yet the genes regulating peroxisome function remain unclear. We performed a genome-wide CRISPRi screen to...
8.
Ali B, Judy R, Chowdhury S, Jacobsen N, Castanzo D, Carr K, et al.
J Biol Chem
. 2023 Nov;
300(1):105504.
PMID: 38036174
The heterohexameric ATPases associated with diverse cellular activities (AAA)-ATPase Pex1/Pex6 is essential for the formation and maintenance of peroxisomes. Pex1/Pex6, similar to other AAA-ATPases, uses the energy from ATP hydrolysis...
9.
Miller A, Chowdhury S, Hanson H, Linderman S, Ghasemi H, Miller W, et al.
bioRxiv
. 2023 Nov;
PMID: 37986852
Aquaporin-1 (Aqp1), a water channel, has garnered significant interest for cell-based medicine and in vivo synthetic biology due to its ability to be genetically encoded to produce magnetic resonance signals...
10.
Ali B, Judy R, Chowdhury S, Jacobsen N, Castanzo D, Carr K, et al.
bioRxiv
. 2023 Sep;
PMID: 37745580
The heterohexameric AAA-ATPase Pex1/Pex6 is essential for the formation and maintenance of peroxisomes. Pex1/Pex6, similar to other AAA-ATPases, uses the energy from ATP hydrolysis to mechanically thread substrate proteins through...