Julie Adam
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Explore the profile of Julie Adam including associated specialties, affiliations and a list of published articles.
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31
Citations
1664
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Recent Articles
1.
Kurlekar S, Lima J, Li R, Lombardi O, Masson N, Barros A, et al.
Cancer Res
. 2024 Mar;
84(11):1799-1816.
PMID: 38502859
Significance: Single-cell analysis of heterogeneous and dynamic responses to Vhl inactivation in the kidney suggests that early events shape the cell type specificity of oncogenesis, providing a focus for mechanistic...
2.
Macklin P, Yamamoto A, Browning L, Hofer M, Adam J, Pugh C
J Pathol
. 2020 Feb;
250(5):593-611.
PMID: 32086807
In this review article, we examine the importance of low levels of oxygen (hypoxia) in cancer biology. We provide a brief description of how mammalian cells sense oxygen. The hypoxia-inducible...
3.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, et al.
Nat Metab
. 2020 Jan;
2(1):32-40.
PMID: 31993555
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon...
4.
McCarthy M, Lin D, Soga T, Adam J, OCallaghan C
Eur J Immunol
. 2019 Aug;
50(1):130-137.
PMID: 31434164
Inosine pranobex (IP) is a synthetic immunomodulating compound, indicated for use in the treatment of human papillomavirus-associated warts and subacute sclerosing panencephalitis. Previous studies demonstrate that the immunomodulatory activity of...
5.
Vergari E, Knudsen J, Ramracheya R, Salehi A, Zhang Q, Adam J, et al.
Nat Commun
. 2019 Jan;
10(1):139.
PMID: 30635569
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of...
6.
Knudsen J, Hamilton A, Ramracheya R, Tarasov A, Brereton M, Haythorne E, et al.
Cell Metab
. 2018 Nov;
29(2):430-442.e4.
PMID: 30415925
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion...
7.
Fielding J, Hodson E, Cheng X, Ferguson D, Eckardt L, Adam J, et al.
J Physiol
. 2018 Jun;
PMID: 29917232
Key Points: The carotid body is a peripheral arterial chemoreceptor that regulates ventilation in response to both acute and sustained hypoxia. Type I cells in this organ respond to low...
8.
McCarthy M, Moncayo G, Hiron T, Jakobsen N, Valli A, Soga T, et al.
J Biol Chem
. 2017 Dec;
293(11):3913-3924.
PMID: 29279329
Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or "stressed" cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA...
9.
Adam J, Ramracheya R, Chibalina M, Ternette N, Hamilton A, Tarasov A, et al.
Cell Rep
. 2017 Sep;
20(13):3135-3148.
PMID: 28954230
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6-8 ...
10.
Manuel A, Walla M, Faccenda A, Martin S, Tanis R, Piroli G, et al.
Antioxid Redox Signal
. 2017 Apr;
27(16):1281-1296.
PMID: 28376661
Aims: Protein succination by fumarate increases in the adipose tissue of diabetic mice and in adipocytes matured in high glucose as a result of glucotoxicity-driven mitochondrial stress. The endoplasmic reticulum...