Julian D Down
Overview
Explore the profile of Julian D Down including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
29
Citations
800
Followers
0
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Recent Articles
1.
Chan Y, Ho P, Dib C, Swartzrock L, Rayburn M, Willner H, et al.
Stem Cell Res Ther
. 2024 Oct;
15(1):387.
PMID: 39473008
Background: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI)...
2.
Down J, Cornwall-Brady M, Huang W, Hurwitz M, Floyd S, Yilmaz O
Radiat Res
. 2024 Jul;
202(3):510-522.
PMID: 39066627
Animal studies are needed that best simulate a large-scale, inhomogeneous body exposure after a radiological or nuclear incident and that provides a platform for future development of medical countermeasures. A...
3.
Schmidt D, Gramatikov I, Sheen A, Williams C, Hurwitz M, Dodge L, et al.
Commun Med (Lond)
. 2023 Aug;
3(1):108.
PMID: 37558833
Background: Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to...
4.
Gibbs A, Gupta P, Mali B, Poirier Y, Gopalakrishnan M, Newman D, et al.
Radiat Res
. 2023 Mar;
199(4):319-335.
PMID: 36857032
The objective of the current study was to establish a mouse model of acute radiation syndrome (ARS) after total-body irradiation with 2.5% bone marrow sparing (TBI/BM2.5) that progressed to the...
5.
Poirier Y, Belley M, Dewhirst M, Yoshizumic T, Down J
Radiat Res
. 2020 Apr;
193(6):506-511.
PMID: 32315248
Many studies in biomedical research and various allied fields, in which cells or laboratory animals are exposed to radiation, rely on adequate radiation dose standardization for reproducibility and comparability of...
6.
Bhukhai K, de Dreuzy E, Giorgi M, Colomb C, Negre O, Denaro M, et al.
Mol Ther
. 2017 Dec;
26(2):480-495.
PMID: 29221807
Although gene transfer to hematopoietic stem cells (HSCs) has shown therapeutic efficacy in recent trials for several individuals with inherited disorders, transduction incompleteness of the HSC population remains a hurdle...
7.
Dabjan M, Buck C, Jackson I, Vujaskovic Z, Marples B, Down J
Lab Invest
. 2016 Aug;
96(9):936-49.
PMID: 27479087
Within this millennium there has been resurgence in funding and research dealing with animal models of radiation-induced lung injury to identify and establish predictive biomarkers and effective mitigating agents that...
8.
Belley M, Ashcraft K, Lee C, Cornwall-Brady M, Chen J, Gunasingha R, et al.
Radiat Res
. 2015 Sep;
184(4):378-91.
PMID: 26401594
To ensure reliability and reproducibility of radiobiological data, it is necessary to standardize dosimetry practices across all research institutions. The photoelectric effect predominates over other interactions at low energy and...
9.
Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann L, et al.
J Radiat Res
. 2014 Nov;
56(2):248-60.
PMID: 25368342
To study the mechanisms of death following a single lethal dose of thoracic radiation, WAG/RijCmcr (Wistar) rats were treated with 15 Gy to the whole thorax and followed until they...
10.
Jackson I, Xu P, Nguyen G, Down J, Johnson C, Katz B, et al.
Health Phys
. 2013 Nov;
106(1):48-55.
PMID: 24276549
Approval of radiation countermeasures through the FDA Animal Rule requires pivotal efficacy screening in one or more species that are expected to react with a response similar to humans (21...